N-(2-hydroxynaphthalen-1-yl)-N-methylbenzamide | 1612838-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-hydroxynaphthalen-1-yl)-N-methylbenzamide
• CAS: 1612838-28-4
• 化学式: C₁₈H₁₅NO₂
• 分子量: 277.323
• InChiKey: HHPCEOGKKLBALX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-甲基-1-萘胺 、 过氧化苯甲酰 在 sodium acetate 作用下， 反应 20.0h， 以77%的产率得到N-(2-hydroxynaphthalen-1-yl)-N-methylbenzamide
  参考文献：
  名称：

  A Facile BPO-Mediated ortho-Hydroxylation and Benzoylation of N-Alkyl Anilines for Synthesis of 2-Benzamidophenols

  摘要：

  A facile benzoyl peroxide (BPO) mediated ortho-hydroxylation and benzoylation of N-alkyl anilines for the synthesis of 2-benzamidophenols has been developed. The reaction tolerates a wide range of functional groups and is a good method for the straightforward synthesis of valuable 2-benzamidophenols in good yields under mild conditions.

  DOI：

  10.1021/ol501293c

文献信息

• A Facile BPO-Mediated <i>ortho</i>-Hydroxylation and Benzoylation of <i>N</i>-Alkyl Anilines for Synthesis of 2-Benzamidophenols
  作者：Zhi-Jing Zhang、Xue-Jing Quan、Zhi-Hui Ren、Yao-Yu Wang、Zheng-Hui Guan

  DOI：10.1021/ol501293c

  日期：2014.6.20

  A facile benzoyl peroxide (BPO) mediated ortho-hydroxylation and benzoylation of N-alkyl anilines for the synthesis of 2-benzamidophenols has been developed. The reaction tolerates a wide range of functional groups and is a good method for the straightforward synthesis of valuable 2-benzamidophenols in good yields under mild conditions.