N-(2-(4-fluorophenyl)-3,7,7-trimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide | 1564277-41-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(2-(4-fluorophenyl)-3,7,7-trimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide
• CAS: 1564277-41-3
• 化学式: C₂₅H₂₅FN₂O₂
• 分子量: 404.484
• InChiKey: NQAYWVNPZVEXON-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  5,5-二甲基-1,3-环己二酮 在 溶剂黄146 、 ethylenediamine Tetraacetic Acid 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.13h， 生成 N-(2-(4-fluorophenyl)-3,7,7-trimethyl-5-oxo-5,6,7,8-tetrahydroquinolin-1(2H)-yl)benzamide
  参考文献：
  名称：

  Microwave-Irradiated Synthesis of 1,2-Dihydropyridines from N-Functionalized Enaminones and Enals through Domino Condensation and 6π-Azaelectrocyclization

  摘要：

  N-Amino-substituted 1,2-dihydropyridine motifs are constructed using cyclohexane-1,3-diones via the Knoevenagel condensation with enals followed by 6 pi-electrocyclization using ethylenediammonium diacetate as a catalyst under MW irradiation. A survey of substituents on the N atom of the enaminones indicated that the phenylamino and benzoylamino groups are favorable for the reaction, while phenyl, benzyl, and no-substituent are not. The substituent at C2 of enals is crucial for smooth formation of the corresponding adducts and slightly higher yields are obtained with enals bearing an electron-withdrawing aromatic at C3.

  DOI：

  10.3987/com-13-12844