(4aR)-1t-hydroxy-10c-acetoxy-2,2,6at,6bc,9,9,12ac-heptamethyl-4ar-acetoxymethyl-(8atH,12btH,14bcH)-Δ¹⁴-eicosahydro-picene | 65063-31-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (4aR)-1t-hydroxy-10c-acetoxy-2,2,6at,6bc,9,9,12ac-heptamethyl-4ar-acetoxymethyl-(8atH,12btH,14bcH)-Δ¹⁴-eicosahydro-picene
• 英文别名: (4aR)-1t-Hydroxy-10c-acetoxy-2,2,6at,6bc,9,9,12ac-heptamethyl-4ar-acetoxymethyl-(8atH,12btH,14bcH)-Δ¹⁴-eicosahydro-picen
• CAS: 65063-31-2
• 化学式: C₃₄H₅₄O₅
• 分子量: 542.8
• InChiKey: XVGPEFOCPRBUTE-HFTLSINTSA-N

反应信息

• 作为产物：
  描述：

  acetic acid-(3β,28-dihydroxy-oleanen-(12)-yl-(19α)-ester) 在 吡啶 、 氢氧化钾 作用下， 生成 (4aR)-1t-hydroxy-10c-acetoxy-2,2,6at,6bc,9,9,12ac-heptamethyl-4ar-acetoxymethyl-(8atH,12btH,14bcH)-Δ¹⁴-eicosahydro-picene
  参考文献：
  名称：

  Modifying Effects of Propolis on MeIQx Promotion of Rat Hepatocarcinogenesis and in a Female Rat Two-Stage Carcinogenesis Model After Multiple Carcinogen Initiation

  摘要：

  The modifying effects of the dietary administration of water- and ethanol-extracted propolis produced in Brazil (WB and EB, respectively) on 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) promotion of rat hepatocarcinogenesis were investigated in a medium-term liver bioassay system with use of male Fischer 344 rats. The number and area of glutathione S-transferase placental form (GST-P)-positive foci in rats given 0.5% WB were significantly increased compared with the group given MeIQx alone. Furthermore, the numbers of GST-P-positive foci were higher in rats given 0.1% WB or EB than in those given the basal diet alone. The modifying effects of propolis on other organs were also examined in female Fischer 344 rats given multiple carcinogens for initiation. Rats received water- and ethanol-extracted propolis produced in Brazil and Uruguay (WB, EB, WU, and EU, respectively) in the diet after exposure to three different carcinogens. The incidence of total mammary tumors was significantly lower in rats given EU than in the control group. These results indicate that a water extract of propolis exerts a cocarcinogenic effect on MeIQx hepatocarcinogenesis while promoting the effect at low dose in a two-stage hepatocarcinogenesis model Moreover, they suggest that ethanol-extracted propolis may be an inhibitor of mammary gland carcinogenesis.

  DOI：

  10.1207/s15327914nc372_10