4-((5-phenoxy-3-pyridinyl)oxy)benzaldehyde | 1446754-48-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-((5-phenoxy-3-pyridinyl)oxy)benzaldehyde
• 英文别名: 4-(5-Phenoxypyridin-3-yl)oxybenzaldehyde；4-(5-phenoxypyridin-3-yl)oxybenzaldehyde
• CAS: 1446754-48-8
• 化学式: C₁₈H₁₃NO₃
• 分子量: 291.306
• InChiKey: IINBZFHXWIUWOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-苯氧基-3-吡啶基)硼酸 、 对硝基苯甲醛 在 C₂₉H₂₆FeN₃Pd⁽¹⁺⁾*Cl^(1-) 、 氧气 、 caesium carbonate 作用下， 以 1,4-二氧六环 、 二甲基亚砜 为溶剂， 反应 24.0h， 以45%的产率得到4-((5-phenoxy-3-pyridinyl)oxy)benzaldehyde
  参考文献：
  名称：

  A 2,2′-bipyridine-palladacycle catalyzed the coupling of arylboronic acids with nitroarenes

  摘要：

  A novel palladium-catalyzed protocol for the synthesis of diaryl ethers derivatives has been developed. In the presence of 2,2'-bipyridine-cyclopalladated ferrocenylimine complex (Cat. Ic), diary] ethers were selectively generated by adjusting reaction parameters through the coupling of arylboronic acids and nitroarenes with yields ranging from poor to good. The efficiency of this reaction was demonstrated by its compatibility with a range of groups. Moreover, the rigorous exclusion of air or moisture was not required in these transformations. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.05.112