N-(1,3-dimethylimidazolidin-2-ylidene)-2-(4-ethylphenyl)-2-(4-methylphenyl)acetamide | 1309977-09-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: N-(1,3-dimethylimidazolidin-2-ylidene)-2-(4-ethylphenyl)-2-(4-methylphenyl)acetamide
• CAS: 1309977-09-0
• 化学式: C₂₂H₂₇N₃O
• 分子量: 349.476
• InChiKey: UMNLUBVKDLBYOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  35.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(4-ethylphenyl)-1-p-tolylethanone 、 2-azido-1,3-dimethylimidazolinium hexafluorophosphate 在 三乙胺 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 0.5h， 以82%的产率得到N-(1,3-dimethylimidazolidin-2-ylidene)-2-(4-ethylphenyl)-2-(4-methylphenyl)acetamide
  参考文献：
  名称：

  Synthesis of α,α-diarylacetamides from benzyl aryl ketones using 2-azido-1,3-dimethylimidazolinium hexafluorophosphate

  摘要：

  Benzyl aryl ketones reacted with 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP, 1) to give migratory amidated compounds, which were transformed into the corresponding diarylacetamides by treating with LiAlH(4). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.042

文献信息

• Synthesis of α,α-diarylacetamides from benzyl aryl ketones using 2-azido-1,3-dimethylimidazolinium hexafluorophosphate
  作者：Mitsuru Kitamura、Satoshi Miyagawa、Tatsuo Okauchi

  DOI：10.1016/j.tetlet.2011.04.042

  日期：2011.6

  Benzyl aryl ketones reacted with 2-azido-1,3-dimethylimidazolinium hexafluorophosphate (ADMP, 1) to give migratory amidated compounds, which were transformed into the corresponding diarylacetamides by treating with LiAlH(4). (C) 2011 Elsevier Ltd. All rights reserved.