1-[(R)-((4S,5S)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methoxy-methyl]-cyclohexanol | 264891-35-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[(R)-((4S,5S)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methoxy-methyl]-cyclohexanol
• CAS: 264891-35-2
• 化学式: C₁₄H₂₆O₅
• 分子量: 274.357
• InChiKey: DFYGUHGXVLXWMW-SDDRHHMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.21
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  68.15
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  1-[(R)-((4S,5S)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methoxy-methyl]-cyclohexanol 在 三氧化硫吡啶 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以66%的产率得到(3a'R,7'R,7a'R)-7'-methoxy-2',2'-dimethyldihydrospiro[cyclohexane-1,6'-[1,3]dioxolo[4,5-c]pyran]-4'(3a'H)-one
  参考文献：
  名称：

  Stereoselective synthesis of 5-monoalkyl and 5,5-dialkylsubstituted noviose derivatives

  摘要：

  fThe stereoselective synthesis of 5-monosubstituted and 5,5-dialkylsubstituted noviose derivatives has been achieved starting from L-arabinose. These noviose derivatives could be used as useful building blocks in probing structure-activity relationships (SAR) of coumarin antibiotics that are inhibitors of DNA gyrase. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)02177-2
• 作为产物：
  描述：

  bromo-[5-(bromomagnesio)pentyl]magnesium 、 (3aS,7R,7aS)-7-Methoxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-one 以 四氢呋喃 为溶剂， 以56%的产率得到1-[(R)-((4S,5S)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methoxy-methyl]-cyclohexanol
  参考文献：
  名称：

  Stereoselective synthesis of 5-monoalkyl and 5,5-dialkylsubstituted noviose derivatives

  摘要：

  fThe stereoselective synthesis of 5-monosubstituted and 5,5-dialkylsubstituted noviose derivatives has been achieved starting from L-arabinose. These noviose derivatives could be used as useful building blocks in probing structure-activity relationships (SAR) of coumarin antibiotics that are inhibitors of DNA gyrase. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)02177-2