(2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-methoxy-6-[(S)-pent-4-enyloxy-((R)-2-thioxo-[1,3]dioxolan-4-yl)-methyl]-tetrahydro-pyran-2-carboxylic acid methyl ester | 374603-97-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-methoxy-6-[(S)-pent-4-enyloxy-((R)-2-thioxo-[1,3]dioxolan-4-yl)-methyl]-tetrahydro-pyran-2-carboxylic acid methyl ester
• CAS: 374603-97-1
• 化学式: C₂₁H₃₁NO₁₀S
• 分子量: 489.544
• InChiKey: LKTHKMKYQKCERH-VCIRBXAFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.78
• 重原子数：
  33.0
• 可旋转键数：
  11.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  127.85
• 氢给体数：
  1.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  (2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-methoxy-6-[(S)-pent-4-enyloxy-((R)-2-thioxo-[1,3]dioxolan-4-yl)-methyl]-tetrahydro-pyran-2-carboxylic acid methyl ester 在 Lindlar's catalyst 四氧化锇 、 Grubbs catalyst first generation 、 sodium azide 、 Dowex 50W (H⁺) 、 硫酸 、 氢气 、 溶剂黄146 、 N-甲基吗啉氧化物 、 三甲氧基磷 作用下， 以 乙醇 、 二氯甲烷 、 丙酮 、 叔丁醇 为溶剂， 生成 (4R,5R,6R)-5-Acetylamino-4-amino-6-((2S,3R,4R)-3,4-diacetoxy-oxepan-2-yl)-5,6-dihydro-4H-pyran-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir

  摘要：

  We synthesized bicyclic ether sialidase inhibitors Such as tetrahydro-furan-2-yl. tetrahydro-pyran-2-yL and oxepan-2-yl derivatives related to zanamivir. These compounds substituted by diol at the C-3' and C-4' positions resulted in the retention of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. Compound I la in particular showed comparable efficacy in vivo relative to that of oseltamivir phosphate. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)01039-9
• 作为产物：
  描述：

  (2S,4S,5R,6R)-5-Acetylamino-6-[(S)-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pent-4-enyloxy-methyl]-4-hydroxy-2-methoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 在 吡啶 、 4-二甲氨基吡啶 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 生成 (2S,4S,5R,6R)-4-Acetoxy-5-acetylamino-2-methoxy-6-[(S)-pent-4-enyloxy-((R)-2-thioxo-[1,3]dioxolan-4-yl)-methyl]-tetrahydro-pyran-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir

  摘要：

  We synthesized bicyclic ether sialidase inhibitors Such as tetrahydro-furan-2-yl. tetrahydro-pyran-2-yL and oxepan-2-yl derivatives related to zanamivir. These compounds substituted by diol at the C-3' and C-4' positions resulted in the retention of low nanomolar inhibitory activities against not only influenza A virus sialidase but also influenza A virus in cell culture. Compound I la in particular showed comparable efficacy in vivo relative to that of oseltamivir phosphate. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)01039-9