9H-fluoren-9-ylmethyl N-[(2S)-1-(4-hydroxyanilino)-1-oxopropan-2-yl]carbamate | 1361510-22-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9H-fluoren-9-ylmethyl N-[(2S)-1-(4-hydroxyanilino)-1-oxopropan-2-yl]carbamate
• CAS: 1361510-22-6
• 化学式: C₂₄H₂₂N₂O₄
• 分子量: 402.45
• InChiKey: VBDGMXJOMXKWBL-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  9H-fluoren-9-ylmethyl N-[(2S)-1-(4-hydroxyanilino)-1-oxopropan-2-yl]carbamate 在 五氯化磷 、 N,N-二甲基甲酰胺 、 selenium 、 lithium aluminium tetrahydride 作用下， 以 苯 、 四氢呋喃 为溶剂， 反应 0.33h， 以86%的产率得到(S)-(9H-fluoren-9-yl)methyl 1-(4-hydroxyphenylamino)-1-selenoxopropan-2-ylcarbamate
  参考文献：
  名称：

  Synthesis of Selenoxo Peptides and Oligoselenoxo Peptides Employing LiAlHSeH

  摘要：

  Synthesis of selenoxo peptides by the treatment of N-a-protected peptide esters with a combination of PCl5 and LiAlHSeH is delineated. The method is simple, high-yielding, and free from racemization. Thus obtained selenoxo peptides are used as unit; for N-terminal chain extension through N-alpha-deprotection/coupling to yield peptide selenoxo peptide hybrids. Multiple selenation is demonstrated by conversion of two peptide bonds of tripeptides into selenoxo peptide bonds. Amino acid derived arylamides are also converted into aryl selenoamides. C6H5-CSeNH-Val-OMe 8f is obtained as single crystal, and its structure was determined through X-ray diffraction study.

  DOI：

  10.1021/jo2024703
• 作为产物：
  描述：

  Fmoc-L-丙氨酸 、 对氨基苯酚 在 N,N'-羰基二咪唑 作用下， 以 四氢呋喃 为溶剂， 以89%的产率得到9H-fluoren-9-ylmethyl N-[(2S)-1-(4-hydroxyanilino)-1-oxopropan-2-yl]carbamate
  参考文献：
  名称：

  Synthesis of Selenoxo Peptides and Oligoselenoxo Peptides Employing LiAlHSeH

  摘要：

  Synthesis of selenoxo peptides by the treatment of N-a-protected peptide esters with a combination of PCl5 and LiAlHSeH is delineated. The method is simple, high-yielding, and free from racemization. Thus obtained selenoxo peptides are used as unit; for N-terminal chain extension through N-alpha-deprotection/coupling to yield peptide selenoxo peptide hybrids. Multiple selenation is demonstrated by conversion of two peptide bonds of tripeptides into selenoxo peptide bonds. Amino acid derived arylamides are also converted into aryl selenoamides. C6H5-CSeNH-Val-OMe 8f is obtained as single crystal, and its structure was determined through X-ray diffraction study.

  DOI：

  10.1021/jo2024703

文献信息

• Synthesis of Selenoxo Peptides and Oligoselenoxo Peptides Employing LiAlHSeH
  作者：T. M. Vishwanatha、N. Narendra、Basab Chattopadhyay、Monika Mukherjee、Vommina V. Sureshbabu

  DOI：10.1021/jo2024703

  日期：2012.3.16

  Synthesis of selenoxo peptides by the treatment of N-a-protected peptide esters with a combination of PCl5 and LiAlHSeH is delineated. The method is simple, high-yielding, and free from racemization. Thus obtained selenoxo peptides are used as unit; for N-terminal chain extension through N-alpha-deprotection/coupling to yield peptide selenoxo peptide hybrids. Multiple selenation is demonstrated by conversion of two peptide bonds of tripeptides into selenoxo peptide bonds. Amino acid derived arylamides are also converted into aryl selenoamides. C6H5-CSeNH-Val-OMe 8f is obtained as single crystal, and its structure was determined through X-ray diffraction study.