| 1253592-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• CAS: 1253592-35-6
• 化学式: C₂F₃O₂*C₂₉H₃₇N₂Si
• 分子量: 554.728
• InChiKey: VIFCFDKUUNQGHY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  39.0
• 可旋转键数：
  0.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  46.38
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-溴甲苯 、 在 仲丁基锂 、 四氯苯醌 作用下， 以 四氢呋喃 为溶剂， 反应 5.5h， 以50%的产率得到
  参考文献：
  名称：

  Development of NIR Fluorescent Dyes Based on Si–rhodamine for in Vivo Imaging

  摘要：

  We have developed a series of novel near-infrared (NIR) wavelength-excitable fluorescent dyes, SiR-NIRs, by modifying the Si-rhodamine scaffold to obtain emission in the range suitable for in vivo imaging. Among them, SiR680 and SiR700 showed sufficiently high quantum efficiency in aqueous media. Both antibody-bound and free dye exhibited high tolerance to photobleaching in aqueous solution. Subcutaneous xenograft tumors were successfully visualized in a mouse tumor model using SiR700-labeled anti-tenascin-C (TN-C) antibody, SiR700-RCB1. SiR-NIRs are expected to be useful as labeling agents for in vivo imaging studies including multicolor imaging, and also as scaffolds for NW fluorescence probes.

  DOI：

  10.1021/ja210375e