1-chloroisoquinolin-7-amine | 1374651-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-chloroisoquinolin-7-amine
• 英文别名: 1-Chloroisoquinolin-7-amine
• CAS: 1374651-74-7
• 化学式: C₉H₇ClN₂
• 分子量: 178.621
• InChiKey: WZOHRRUGZFEWGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-chloroisoquinolin-7-amine 在 tris-(dibenzylideneacetone)dipalladium(0) 、 caesium carbonate 、 1-丙基磷酸酐 、 N,N-二异丙基乙胺 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 18.0h， 生成 N-(1-((3-chloro-4-methylphenyl)amino)isoquinolin-7-yl)-4-(piperidin-1-yl)butanamide
  参考文献：
  名称：

  [EN] ISOQUINOLINE DERIVATIVES AS INHIBITORS OF BAX AND/OR BAK, COMPOSITIONS AND USES THEREOF
  [FR] DÉRIVÉS D'ISOQUINOLINE UTILISÉS EN TANT QU'INHIBITEURS DE BAX ET/OU DE BAK, COMPOSITIONS ET UTILISATIONS ASSOCIÉES

  摘要：

  The present application relates to isoquinoline compounds of Formula (I), to processes for their preparation and to compositions comprising them. More particularly, the present application relates to compound of Formula (I) that have activity as inhibitors of Bcl2- associated X protein (BAX) and/or Bcl-2 antagonist killer (BAK), and to their use in the treatment of diseases, disorders or conditions treatable by inhibiting BAX and/or BAK such as neurodegenerative diseases, disorders or conditions.

  公开号：

  WO2023155019A1
• 作为产物：
  描述：

  1-氯-7-硝基异喹啉 在 铁粉 、 氯化铵 作用下， 以 甲醇 、 氘代四氢呋喃 、 水 为溶剂， 以70.1 %的产率得到1-chloroisoquinolin-7-amine
  参考文献：
  名称：

  [EN] ISOQUINOLINE DERIVATIVES AS INHIBITORS OF BAX AND/OR BAK, COMPOSITIONS AND USES THEREOF
  [FR] DÉRIVÉS D'ISOQUINOLINE UTILISÉS EN TANT QU'INHIBITEURS DE BAX ET/OU DE BAK, COMPOSITIONS ET UTILISATIONS ASSOCIÉES

  摘要：

  The present application relates to isoquinoline compounds of Formula (I), to processes for their preparation and to compositions comprising them. More particularly, the present application relates to compound of Formula (I) that have activity as inhibitors of Bcl2- associated X protein (BAX) and/or Bcl-2 antagonist killer (BAK), and to their use in the treatment of diseases, disorders or conditions treatable by inhibiting BAX and/or BAK such as neurodegenerative diseases, disorders or conditions.

  公开号：

  WO2023155019A1

文献信息

• [EN] ISOQUINOLINE DERIVATIVES AS INHIBITORS OF BAX AND/OR BAK, COMPOSITIONS AND USES THEREOF<br/>[FR] DÉRIVÉS D'ISOQUINOLINE UTILISÉS EN TANT QU'INHIBITEURS DE BAX ET/OU DE BAK, COMPOSITIONS ET UTILISATIONS ASSOCIÉES
  申请人：[en]SUNNYBROOK RESEARCH INSTITUTE

  公开号：WO2023155019A1

  公开（公告）日：2023-08-24

  The present application relates to isoquinoline compounds of Formula (I), to processes for their preparation and to compositions comprising them. More particularly, the present application relates to compound of Formula (I) that have activity as inhibitors of Bcl2- associated X protein (BAX) and/or Bcl-2 antagonist killer (BAK), and to their use in the treatment of diseases, disorders or conditions treatable by inhibiting BAX and/or BAK such as neurodegenerative diseases, disorders or conditions.