4-fluoro-2-isopropyl-5-methyl-anisole | 445-92-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-fluoro-2-isopropyl-5-methyl-anisole
• 英文别名: 4-Fluor-2-isopropyl-5-methyl-anisol；1-Fluoro-4-methoxy-2-methyl-5-propan-2-ylbenzene；1-fluoro-4-methoxy-2-methyl-5-propan-2-ylbenzene
• CAS: 445-92-1
• 化学式: C₁₁H₁₅FO
• 分子量: 182.238
• InChiKey: AVBOPELFFGHUSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-fluoro-2-isopropyl-5-methyl-anisole 在 氢碘酸 作用下， 生成 4-fluoro-2-isopropyl-5-methylphenol
  参考文献：
  名称：

  Hach, Chemicke Listy, 1954, vol. 48, p. 1707

  摘要：

  DOI：
• 作为产物：
  描述：

  4-Amino-O-methyl-thymol 在 tetrafluoroboric acid 、 sodium nitrite 作用下， 生成 4-fluoro-2-isopropyl-5-methyl-anisole
  参考文献：
  名称：

  Hach, Chemicke Listy, 1954, vol. 48, p. 1707

  摘要：

  DOI：

文献信息

• REAGENTS AND METHODS FOR REPLICATION, TRANSCRIPTION, AND TRANSLATION IN SEMI-SYNTHETIC ORGANISMS
  申请人：The Scripps Research Institute

  公开号：US20200392550A1

  公开（公告）日：2020-12-17

  Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.

  本文揭示了一种用于增加含有一个或多个非天然氨基酸的蛋白质或多肽的生产的组合物、方法、细胞、工程微生物和试剂盒。此外，还提供了一种用于增加编码非天然氨基酸的非天然核酸在工程细胞或半合成生物体中的保留的组合物、细胞、工程微生物和试剂盒。
• Pyran-Spirocyclic Piperidine Amides as Modulators of Ion Channels
  申请人：Vertexs Pharmaceuticals Incorporated

  公开号：US20150005304A1

  公开（公告）日：2015-01-01

  The invention relates to pyran spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

  本发明涉及一种吡喃螺环哌啶酰胺化合物，可用作离子通道的抑制剂。本发明还提供了包含本发明化合物的药学上可接受的组合物，并提供了使用这些组合物治疗各种疾病的方法。
• Nucleoside triphosphate transporter and uses thereof
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US10696719B2

  公开（公告）日：2020-06-30

  Disclosed herein are proteins, methods, cells, engineered microorganisms, and kits for generating a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum. Also disclosed herein proteins, methods, cells, engineered microorganisms, and kits for production of a nucleic acid molecule that comprises an unnatural nucleotide utilizing a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum.

  本文公开了蛋白质、方法、细胞、工程微生物和试剂盒，用于从三疣藻中产生修饰的核苷三磷酸转运体。本文还公开了利用来自 Phaeodactylum tricornutum 的改良三磷酸核苷转运体生产包含非天然核苷酸的核酸分子的蛋白质、方法、细胞、工程微生物和试剂盒。
• IL-2 conjugates and methods of use thereof
  申请人：Synthorx, Inc.

  公开号：US11077195B2

  公开（公告）日：2021-08-03

  Disclosed herein are compositions, kits, and methods comprising interleukin (IL) conjugates (e.g., IL-2 conjugates) useful for the treatment of one or more indications. Also described herein are pharmaceutical compositions and kits comprising one or more of the interleukin conjugates (e.g., IL-2 conjugates).

  本文公开了包含白细胞介素（IL）共轭物（如IL-2共轭物）的组合物、试剂盒和方法，可用于治疗一种或多种适应症。本文还描述了包含一种或多种白细胞介素共轭物（如 IL-2 共轭物）的药物组合物和试剂盒。
• MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
  申请人：Miller Mark Thomas

  公开号：US20170196862A2

  公开（公告）日：2017-07-13

  The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R 1 , R 2 , R 3 , W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.