ethyl 1'-cyclopropyl-8'-methyl-6'-nitro-4,4'-dioxo-7-(trifluoromethyl)-1',4'-dihydro-4H-1,7'-biquinoline-3'-carboxylate | 1643811-60-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 1'-cyclopropyl-8'-methyl-6'-nitro-4,4'-dioxo-7-(trifluoromethyl)-1',4'-dihydro-4H-1,7'-biquinoline-3'-carboxylate
• CAS: 1643811-60-2
• 化学式: C₂₆H₂₀F₃N₃O₆
• 分子量: 527.457
• InChiKey: JENFEIWSNXLNSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.05
• 重原子数：
  38.0
• 可旋转键数：
  5.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  113.44
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  ethyl 1'-cyclopropyl-8'-methyl-6'-nitro-4,4'-dioxo-7-(trifluoromethyl)-1',4'-dihydro-4H-1,7'-biquinoline-3'-carboxylate 在 氢气 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以80%的产率得到ethyl 6'-amino-1'-cyclopropyl-8'-methyl-4,4'-dioxo-7-(trifluoromethyl)-1',4'-dihydro-4H-1,7'-biquinoline-3'-carboxylate
  参考文献：
  名称：

  Ethyl 1,8-Naphthyridone-3-carboxylates Downregulate Human Papillomavirus-16 E6 and E7 Oncogene Expression

  摘要：

  Strong epidemiological and molecular data associate cervical cancer (CC) with high-risk human papillomavirus (HPV) infections. The carcinogenic mechanism depends mainly on the expression of E6 and E7 oncoproteins encoded by the viral genome. Using a cell-based high-throughput assay, an in-house library of compounds was screened identifying the 1,8-naphthyridone 1 that efficiently inhibited the transcription driven by the long control region of the HPV genome. A series of analogues were then synthesized, obtaining more potent derivatives able to downregulate E6 and E7 transcripts in HPV-16-positive CC CaSki cells. An unusual structural insight emerged for the C-3 position of the 1,8-naphthyridone core, where the ethyl carboxylate esters, but not the carboxylic acids, are responsible for the activity. In vitro uptake studies showed that the 3-ethyl carboxylates do not act as prodrugs. The 1,8-naphthyridones emerged as valid starting points for the development of innovative agents potentially useful for the treatment of HPV-induced CC.

  DOI：

  10.1021/jm500340h
• 作为产物：
  描述：

  7-（三氯甲基）-4-羟基喹啉 、 ethyl 7-chloro-1-cyclopropyl-1,4-dihydro-8-methyl-6-nitro-4-oxoquinolone-3-carboxylate 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 120.0 ℃ 、500.01 kPa 条件下， 反应 0.03h， 以71%的产率得到ethyl 1'-cyclopropyl-8'-methyl-6'-nitro-4,4'-dioxo-7-(trifluoromethyl)-1',4'-dihydro-4H-1,7'-biquinoline-3'-carboxylate
  参考文献：
  名称：

  Ethyl 1,8-Naphthyridone-3-carboxylates Downregulate Human Papillomavirus-16 E6 and E7 Oncogene Expression

  摘要：

  Strong epidemiological and molecular data associate cervical cancer (CC) with high-risk human papillomavirus (HPV) infections. The carcinogenic mechanism depends mainly on the expression of E6 and E7 oncoproteins encoded by the viral genome. Using a cell-based high-throughput assay, an in-house library of compounds was screened identifying the 1,8-naphthyridone 1 that efficiently inhibited the transcription driven by the long control region of the HPV genome. A series of analogues were then synthesized, obtaining more potent derivatives able to downregulate E6 and E7 transcripts in HPV-16-positive CC CaSki cells. An unusual structural insight emerged for the C-3 position of the 1,8-naphthyridone core, where the ethyl carboxylate esters, but not the carboxylic acids, are responsible for the activity. In vitro uptake studies showed that the 3-ethyl carboxylates do not act as prodrugs. The 1,8-naphthyridones emerged as valid starting points for the development of innovative agents potentially useful for the treatment of HPV-induced CC.

  DOI：

  10.1021/jm500340h