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(3RS,4S)-4-(2-methyl-3-hydroxy-8-(trimethylsilyl)-oct-7-in-2-yl)-2,2-dimethyl-[1,3]dioxane | 303154-54-3

中文名称
——
中文别名
——
英文名称
(3RS,4S)-4-(2-methyl-3-hydroxy-8-(trimethylsilyl)-oct-7-in-2-yl)-2,2-dimethyl-[1,3]dioxane
英文别名
2-[(4S)-2,2-dimethyl-1,3-dioxan-4-yl]-2-methyl-8-trimethylsilyloct-7-yn-3-ol
(3RS,4S)-4-(2-methyl-3-hydroxy-8-(trimethylsilyl)-oct-7-in-2-yl)-2,2-dimethyl-[1,3]dioxane化学式
CAS
303154-54-3
化学式
C18H34O3Si
mdl
——
分子量
326.552
InChiKey
MDOUSLTWXICCIK-LYKKTTPLSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.97
  • 重原子数:
    22
  • 可旋转键数:
    6
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.89
  • 拓扑面积:
    38.7
  • 氢给体数:
    1
  • 氢受体数:
    3

反应信息

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文献信息

  • 6-Alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
    申请人:Klar Ulrich
    公开号:US20050113429A1
    公开(公告)日:2005-05-26
    This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R 1a , R 1b , R 2b , R 3a , R 3b , R 4 , R 5 , R 6 , R 7 , A, Y, D, E, G, Y and Z have the meanings that are indicated in the description. The new compounds interact with tubulin by stabilizing microtubuli that are formed. They are able to influence the cell-splitting in a phase-specific manner and thus find use in treating diseases or conditions associated with the need for cell growth, division and/or proliferation. Thus the compounds are suitable for treating malignant tumors, for example, ovarian, stomach, colon, adeno-, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are suitable for anti-angiogenesis therapy as well as for treatment of chronic inflammatory diseases (such as psoriasis, arthritis). Methods of use and preparation of the compounds are also described.
    该发明描述了通式(I)中的新6-烯基-和6-炔基-epothilone衍生物,其中R1a、R1b、R2b、R3a、R3b、R4、R5、R6、R7、A、Y、D、E、G、Y和Z具有说明中指示的含义。这些新化合物通过稳定形成的微管蛋白质与微管结合。它们能够以特定阶段的方式影响细胞分裂,因此可用于治疗与细胞生长、分裂和/或增殖需求相关的疾病或状况。因此,这些化合物适用于治疗恶性肿瘤,例如卵巢、胃、结肠、腺癌、乳腺、肺、头颈癌、恶性黑色素瘤、急性淋巴细胞和骨髓性白血病。此外,它们也适用于抗血管生成治疗以及慢性炎症性疾病的治疗(如牛皮癣、关节炎)。还描述了这些化合物的使用方法和制备方法。
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