4-benzyloxy-3-iodo-2,6-dimethylpyridine | 138621-05-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-benzyloxy-3-iodo-2,6-dimethylpyridine
• 英文别名: 3-Iodo-2,6-dimethyl-4-phenylmethoxypyridine
• CAS: 138621-05-3
• 化学式: C₁₄H₁₄INO
• 分子量: 339.176
• InChiKey: JAQWJVMIWWVOEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-benzyloxy-3-iodo-2,6-dimethylpyridine 在 palladium on activated charcoal 四(三苯基膦)钯 、 氢气 、 sodium hydride 、 锌 作用下， 以 甲醇 为溶剂， 反应 4.5h， 生成 3-Benzyl-2,6-dimethyl-4-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethoxy]-pyridine
  参考文献：
  名称：

  New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy)pyridine derivatives

  摘要：

  A novel series of nonpeptide angiotensin II (AII) receptor antagonists is reported, derived from linkage of the biphenylyltetrazole moiety found in previously described antagonists via a methyleneoxy chain to the 4-position of a 3-substituted 2,6-dialkylpyridine. When evaluated in an in vitro binding assay using a guinea pig adrenal membrane preparation, compounds in this series generally gave IC50 values in the range 0.005-0.5 muM. A variety of substituents was found to be effective at the 3-position of the pyridine ring. On intravenous administration in a normotensive rat model, the more potent compounds inhibited the AII-induced pressor response with ED50 values in the range 0.1-1.0 mg/kg. One of the compounds, 2-ethyl-5,6,7,8-tetrahydro-4-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methoxy}quinoline (26), demonstrated good oral activity in two rat models. At doses in the range 1-10 mg/kg po in AII-infused, conscious, normotensive rats, the compound exhibited a dose-related inhibition of the pressor response with a good duration of action at the higher doses. In a renal hypertensive rat model compound 26 showed a rapid and sustained lowering of blood pressure at a dose of 5 mg/kg po. Based on its profile, this compound, designated ICI D6888, has been selected for evaluation in volunteers.

  DOI：

  10.1021/jm00061a016
• 作为产物：
  描述：

  氯化苄 、 1,4-Dihydro-2,6-dimethyl-3-iodo-4-oxopyridine 以 水 、 N,N-二甲基甲酰胺 为溶剂， 生成 4-benzyloxy-3-iodo-2,6-dimethylpyridine
  参考文献：
  名称：

  Pyridine compounds which are useful as angiotensin II receptor

  摘要：

  本发明涉及公式I的具有药用价值的化合物，其中R.sup.1，R.sup.2，R.sup.3，R.sup.4，R.sup.5，R.sup.6，R.sup.7，X和Z具有本文中定义的各种含义，以及它们的非毒性盐和含有它们的制药组合物。这些新型化合物在治疗高血压和充血性心力衰竭等疾病方面具有价值。本发明还涉及制造这些新型化合物的工艺以及将这些化合物用于医疗治疗的用途。

  公开号：

  US05236936A1

文献信息

• PYRIDINE COMPOUND AND USE THEREOF
  申请人：NIPPON SODA CO., LTD.

  公开号：US20190071403A1

  公开（公告）日：2019-03-07

  The present invention provides a compound represented by formula (I) (in the formula, R 1 to R 4 each represent a hydrogen atom, an unsubstituted or G 1 -substituted C1-6 alkyl group or the like, A represents an oxygen atom or the like, Cy represents a C6-10 aryl group or the like), an N-oxide compound thereof, a tautomer or salt thereof. The present invention also provides an agricultural and horticultural fungicide, harmful organism control agent and insecticidal/acaricidal agent containing at least one compound selected from the group consisting of a compound represented by formula (I), a tautomer and salt thereof, as an active ingredient.

  本发明提供一种由式(I)表示的化合物（在该式中，R1至R4分别表示氢原子，未取代或G1取代的C1-6烷基或类似物，A表示氧原子或类似物，Cy表示C6-10芳基或类似物），其N-氧化物化合物，其互变异构体或盐。本发明还提供一种农业和园艺杀菌剂，有害生物控制剂和杀虫/杀螨剂，其含有从由式(I)表示的化合物、其互变异构体和盐中选择的至少一种化合物作为活性成分的组合。
• Angiotensin II antagonizers which are condensed pyridine derivatives
  申请人：Imperial Chemical Industries PLC

  公开号：US05130318A1

  公开（公告）日：1992-07-14

  The invention concerns pharmaceutically useful novel compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

  这项发明涉及具有以下结构的药用新化合物（公式I），其中R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5、R.sup.6、R.sup.7、X和Z具有此处定义的各种含义，以及它们的无毒盐和含有它们的药物组合物。这些新化合物对于治疗高血压和充血性心力衰竭等疾病具有价值。该发明还涉及制造这些新化合物的过程以及将这些化合物用于医疗治疗的用途。
• Pyridine derivatives
  申请人：ZENECA LIMITED

  公开号：EP0453210A2

  公开（公告）日：1991-10-23

  The invention concerns pharmaceutically useful novel compounds of the formula I, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

  本发明涉及在医药上有用的式 I 新型化合物及其无毒盐，以及含有它们的药物组合物。这些新型化合物具有治疗高血压和充血性心力衰竭等疾病的价值。本发明还涉及新型化合物的生产工艺以及这些化合物在医疗中的用途。
• Pyridine compounds as angiotensin II antagonists, processes for their preparation and pharmaceutical compositions containing them
  申请人：ZENECA LIMITED

  公开号：EP0499416A2

  公开（公告）日：1992-08-19

  The invention concerns pharmaceutically useful compounds of formulae I-Ic, in which R1, R2, R3, R4, R5, R6, R7, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

  本发明涉及式 I-Ic 的药用化合物（其中 R1、R2、R3、R4、R5、R6、R7、X 和 Z 具有本文所定义的各种含义）及其无毒盐和含有它们的药物组合物。这些新型化合物具有治疗高血压和充血性心力衰竭等疾病的价值。本发明还涉及新型化合物的生产工艺以及这些化合物在医疗中的应用。
• Pyridine compound and use thereof
  申请人：Nippon Soda Co., Ltd.

  公开号：US10781177B2

  公开（公告）日：2020-09-22

  The present invention provides a compound represented by formula (I) (in the formula, R1 to R4 each represent a hydrogen atom, an unsubstituted or G1-substituted C1-6 alkyl group or the like, A represents an oxygen atom or the like, Cy represents a C6-10 aryl group or the like), an N-oxide compound thereof, a tautomer or salt thereof. The present invention also provides an agricultural and horticultural fungicide, harmful organism control agent and insecticidal/acaricidal agent containing at least one compound selected from the group consisting of a compound represented by formula (I), a tautomer and salt thereof, as an active ingredient.

  本发明提供一种由式(I)代表的化合物(式中，R1至R4各自代表氢原子、未取代或G1-取代的C1-6烷基或类似物，A代表氧原子或类似物，Cy代表C6-10芳基或类似物)、其N-氧化物化合物、其同系物或盐。本发明还提供了一种农业和园艺杀菌剂、有害生物防治剂和杀虫/杀螨剂，其活性成分至少含有一种选自由式（I）代表的化合物、其同系物和盐组成的组中的化合物。