(S)-2-(tert-butyldiphenylsilyloxymethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indole | 257876-32-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (S)-2-(tert-butyldiphenylsilyloxymethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indole
• 英文别名: tert-butyl-[[(2S)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-2-yl]methoxy]-diphenylsilane
• CAS: 257876-32-7
• 化学式: C₂₈H₃₁NOSi
• 分子量: 425.646
• InChiKey: XBSNZWHKJJCUTP-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.39
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  14.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (S)-2-(tert-butyldiphenylsilyloxymethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indole 在 吡啶 、 三乙基硅烷 、 sodium tetrahydroborate 、 potassium tert-butylate 、 四丁基氟化铵 、 溶剂黄146 、 三乙胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 8.5h， 生成 3-anilino-4-[(2R)-2-(diethylaminomethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-4-yl]pyrrole-2,5-dione
  参考文献：
  名称：

  Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCβ-selective inhibitors

  摘要：

  Conformationally restricted 3-anilino-4-(3-indolyl)maleimide derivatives were designed and synthesized aiming at discovery of novel protein kinase C beta (PKC beta)-selective inhibitors possessing oral bioavailability. Among them, compounds having a fused five-membered ring at the indole 1,2-position inhibited PKC beta 2 with IC50 of nM-order and showed good oral bioavailability. One of the most potent compounds was found to be PKC beta-selective over other 6 isozymes and exhibited ameliorative effects in a rat diabetic retinopathy model via oral route. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.05.033
• 作为产物：
  描述：

  在 sodium hydride 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以84%的产率得到(S)-2-(tert-butyldiphenylsilyloxymethyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indole
  参考文献：
  名称：

  Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCβ-selective inhibitors

  摘要：

  Conformationally restricted 3-anilino-4-(3-indolyl)maleimide derivatives were designed and synthesized aiming at discovery of novel protein kinase C beta (PKC beta)-selective inhibitors possessing oral bioavailability. Among them, compounds having a fused five-membered ring at the indole 1,2-position inhibited PKC beta 2 with IC50 of nM-order and showed good oral bioavailability. One of the most potent compounds was found to be PKC beta-selective over other 6 isozymes and exhibited ameliorative effects in a rat diabetic retinopathy model via oral route. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.05.033