| 1023924-85-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 1023924-85-7
• 化学式: C₇₃H₈₀N₂O₁₁S₃
• 分子量: 1257.64
• InChiKey: SWBNMLIWGONEOD-AMTFUCPOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.33
• 重原子数：
  89.0
• 可旋转键数：
  30.0
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  167.95
• 氢给体数：
  3.0
• 氢受体数：
  12.0

反应信息

• 作为产物：
  描述：

  4-ethenyl-N-[(1R,2R)-2-[[(1S,2R,4R)-2-hydroxy-7,7-dimethyl-1-bicyclo[2.2.1]heptanyl]methylsulfonylamino]cyclohexyl]benzenesulfonamide 、 [3,5-双[[3,5-双(苯甲氧基)苯基]甲氧基]苯基]甲硫醇 在 偶氮二异丁腈 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以62%的产率得到
  参考文献：
  名称：

  Toward the continuous-flow synthesis of chiral tertiary alcohols by enantioselective addition of organozinc reagents to ketones using nanosize isoborneol ligands

  摘要：

  The catalytic enantio selective addition of different organozinc reagents, such as alkyl or in situ generated phenylzinc derivatives to simple aryl ketones, was accomplished using titanium tetraisopropoxide and chiral ligands derived from trans-1-arenesulfonylamino-2-isoborneolsulfonylamidocyclohexane and Frechet-type dendrons with up to 2.5 nin of diameter, giving the corresponding tertiary alcohols with enantioselectivities up to >99%. A simple and efficient procedure for the synthesis of the ligands used is also described, involving the radical addition of the corresponding thiol dendron to the chiral styryl-isoborneol derivative. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.02.002