3β,19α,23,24-tetrahydroxy-urs-12-en-28-oic acid | 1033282-12-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β,19α,23,24-tetrahydroxy-urs-12-en-28-oic acid
• 英文别名: 3β,19α,23β,24α-tetrahydroxyurs-12-en-28-oic acid；(1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1,10-dihydroxy-9,9-bis(hydroxymethyl)-1,2,6a,6b,12a-pentamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
• CAS: 1033282-12-0
• 化学式: C₃₀H₄₈O₆
• 分子量: 504.708
• InChiKey: MDDPTIWFHAUVPJ-ITSMGLEJSA-N

反应信息

• 作为反应物：
  描述：

  3β,19α,23,24-tetrahydroxy-urs-12-en-28-oic acid 、 乙酸酐 在 吡啶 作用下， 反应 48.0h， 生成
  参考文献：
  名称：

  New ursane-type triterpene with NO production suppressing activity from Nauclea officinalis

  摘要：

  Two new ursane- type triterpenes, named as 3 beta, 19 alpha, 23, 24-tetrahydroxyurs-12-en-28-oic acid (1) and 2b, 3 beta, 19 alpha, 24-tetrahydroxyurs-12-en-28-oic acid (2), together with two known triterpenoids, 3-oxo-urs-12-ene-27, 28-dioic acid (3) and quinovic acid-3 beta- rhamnopyranoside (4), were isolated from the stems (with barks) of Nauclea officinalis. The structures of 1 and 2 were determined by the combined use of singlecrystal X-ray diffraction and spectroscopic data analysis. The inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells were examined, and compound 1 was found to inhibit NO production, with the IC50 value of 4.8mM.

  DOI：

  10.1080/10286020.2011.628839