methylnovolactone | 1804950-47-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: methylnovolactone
• 英文别名: 1-Phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,4b,5,8,8a,9,10,10a-dodecahydro-10,10a-dihydroxy-2-methoxy-1,4a,8-trimethyl-, (1S,2S,4aR,4bS,8R,8aS,10R,10aS)-；(1S,2S,4aR,4bS,8R,8aS,10R,10aS)-7-ethenyl-10,10a-dihydroxy-2-methoxy-1,4a,8-trimethyl-3,4,4b,5,8,8a,9,10-octahydro-2H-phenanthrene-1-carboxylic acid
• CAS: 1804950-47-7
• 化学式: C₂₁H₃₂O₅
• 分子量: 364.482
• InChiKey: UMZQHKFAEKCTRE-ZWIYXXKXSA-N

反应信息

• 作为产物：
  描述：

  甲醇 、 novolactone 反应 120.0h， 生成 methylnovolactone
  参考文献：
  名称：

  The Novolactone Natural Product Disrupts the Allosteric Regulation of Hsp70

  摘要：

  The highly conserved 70 kDa heat shock proteins (Hsp70) play an integral role in proteostasis such that dysregulation has been implicated in numerous diseases. Elucidating the precise role of Hsp70 family members in the cellular context, however, has been hampered by the redundancy and intricate regulation of the chaperone network, and relatively few selective and potent tools. We have characterized a natural product, novolactone, that targets cytosolic and ER-localized isoforms of Hsp70 through a highly conserved covalent interaction at the interface between the substrate-binding and ATPase domains. Biochemical and structural analyses indicate that novolactone disrupts interdomain communication by allosterically inducing a conformational change in the Hsp70 protein to block ATP-induced substrate release and inhibit refolding activities. Thus, novolactone is a valuable tool for exploring the requirements of Hsp70 chaperones in diverse cellular contexts.

  DOI：

  10.1016/j.chembiol.2014.11.007