9-methyltetrazolo[1,5-a]quinoline-4-carbonitrile | 1242770-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-methyltetrazolo[1,5-a]quinoline-4-carbonitrile
• CAS: 1242770-43-9
• 化学式: C₁₁H₇N₅
• 分子量: 209.21
• InChiKey: IHKIGFUOCUDIHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  66.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-8-甲基喹啉-3-甲醛 在 甲酸 、 sodium azide 、 盐酸羟胺 、 溶剂黄146 作用下， 以 二甲基亚砜 为溶剂， 反应 3.0h， 生成 9-methyltetrazolo[1,5-a]quinoline-4-carbonitrile
  参考文献：
  名称：

  Erratum to: Synthesis and antimicrobial activity of tetrazolo[1,5-a]quinoline-4-carbonitrile derivatives

  摘要：

  DOI：

  10.1007/s00706-010-0356-7

文献信息

• Synthesis and antimicrobial activity of tetrazolo[1,5-a]quinoline-4-carbonitrile derivatives
  作者：Amol H. Kategaonkar、Vilas B. Labade、Pravin V. Shinde、Atul H. Kategaonkar、Bapurao B. Shingate、Murlidhar S. Shingare

  DOI：10.1007/s00706-010-0324-2

  日期：2010.7

  A series of new tetrazolo[1,5-a]quinoline-4-carbonitrile derivatives were synthesized for the first time via tetrazolo[1,5-a]quinoline derivatives. Elemental analysis, IR, (1)H NMR, (13)C NMR, and mass spectral data were used to elucidate the structures of all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds were investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli, and two fungi, Candida albicans and Aspergillus niger, in comparison with standard drugs. Some of the tested compounds showed significant antimicrobial activity.
• Erratum to: Synthesis and antimicrobial activity of tetrazolo[1,5-a]quinoline-4-carbonitrile derivatives
  作者：Amol H. Kategaonkar、Vilas B. Labade、Pravin V. Shinde、Atul H. Kategaonkar、Bapurao B. Shingate、Murlidhar S. Shingare

  DOI：10.1007/s00706-010-0356-7

  日期：2010.8