quinacridone-1'-α-deoxyriboside-3',5'-di-O-(p-toluoyl) ester | 667458-06-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: quinacridone-1'-α-deoxyriboside-3',5'-di-O-(p-toluoyl) ester
• CAS: 667458-06-2
• 化学式: C₄₁H₃₂N₂O₇
• 分子量: 664.714
• InChiKey: UFYMWBUWKNPSOW-QOEXFKEZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.14
• 重原子数：
  50.0
• 可旋转键数：
  6.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  116.69
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  quinacridone-1'-α-deoxyriboside-3',5'-di-O-(p-toluoyl) ester 在 sodium methylate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 4.0h， 以59%的产率得到quinacridone-1'-α-deoxyriboside
  参考文献：
  名称：

  Libraries of Composite Polyfluors Built from Fluorescent Deoxyribosides

  摘要：

  We report on a new class of water-soluble fluorescent molecules (polyfluors) that are composed of multiple individual fluorophores assembled on a DNA-like backbone. Four fluorophore deoxyribosides were synthesized, and these individual molecules were assembled into oligofluor strings on a DNA synthesizer. A library of 256 tetrafluors was generated by split and pool methods on polystyrene beads. Images of the library under a fluorescence microscope revealed at least 40-50 different hues and intensities. Selected tetrafluors were resynthesized in pure form in solution and displayed properties, such as large Stokes shifts, that individual fluorophores do not have.

  DOI：

  10.1021/ja027197a
• 作为产物：
  描述：

  喹吖啶酮 、 1-Α-氯-3,5-二-O-对甲苯甲酰基-2-脱氧-D-呋喃核糖 在 sodium hydride 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 24.25h， 以8.4%的产率得到quinacridone-1'-α-deoxyriboside-3',5'-di-O-(p-toluoyl) ester
  参考文献：
  名称：

  Libraries of Composite Polyfluors Built from Fluorescent Deoxyribosides

  摘要：

  We report on a new class of water-soluble fluorescent molecules (polyfluors) that are composed of multiple individual fluorophores assembled on a DNA-like backbone. Four fluorophore deoxyribosides were synthesized, and these individual molecules were assembled into oligofluor strings on a DNA synthesizer. A library of 256 tetrafluors was generated by split and pool methods on polystyrene beads. Images of the library under a fluorescence microscope revealed at least 40-50 different hues and intensities. Selected tetrafluors were resynthesized in pure form in solution and displayed properties, such as large Stokes shifts, that individual fluorophores do not have.

  DOI：

  10.1021/ja027197a