6-methyl-4-methylamino-pyrano<3,2-c>quinolin-2,5(6H)-dione | 71509-15-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methyl-4-methylamino-pyrano<3,2-c>quinolin-2,5(6H)-dione
• 英文别名: 6-methyl-4-methylamino-6H-pyrano[3,2-c]quinoline-2,5-dione；6-Methyl-4-methylamino-pyran<3,2-c>chinolin-2,5(6H)-dion；6-Methyl-4-(methylamino)pyrano[3,2-c]quinoline-2,5-dione
• CAS: 71509-15-4
• 化学式: C₁₄H₁₂N₂O₃
• 分子量: 256.261
• InChiKey: VWEHRUSHKYBSHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-methyl-4-methylamino-pyrano<3,2-c>quinolin-2,5(6H)-dione 在 氢氧化钾 作用下， 以83%的产率得到3-乙酰基-4-羟基-1-甲基-2(1H)-喹啉酮
  参考文献：
  名称：

  Syntheses of 3-Acyl-4-hydroxy-2(1H)quinolones

  摘要：

  3-Acyl-4-hydroxy-2(1H)-quinolones 5 are obtained by hydrolytic ring opening and subsequent decarboxylation from the corresponding pyrano[3,2-c]quinolin-2,5(6H)-diones 4, which in turn are easily obtained from 1:2 condensation of anilines 1 with diethyl malonate 2a or 1:1 condensation of diethyl alkyl- or arylmalonates 2b-e with 4-hydroxy-2(1H)-quinolones 3. Nitropyranoquinolinediones 6 furnish after ringopening 3-nitroacetyl-4-hydroxy-2(1H)quinolones 8. Pyranoquinolines 7 and 9 with acetyl- or aminosubstituents are hydrolyzed during basic ringopening to yield 5.

  DOI：

  10.1002/prac.19943360707
• 作为产物：
  描述：

  1,3-二甲基脲 、 4-羟基-6-甲基-2H-吡喃[3,2-c]喹啉-2,5(6h)-二酮 在 盐酸甲胺 作用下， 反应 1.0h， 以52%的产率得到6-methyl-4-methylamino-pyrano<3,2-c>quinolin-2,5(6H)-dione
  参考文献：
  名称：

  Syntheses of 3-Acyl-4-hydroxy-2(1H)quinolones

  摘要：

  3-Acyl-4-hydroxy-2(1H)-quinolones 5 are obtained by hydrolytic ring opening and subsequent decarboxylation from the corresponding pyrano[3,2-c]quinolin-2,5(6H)-diones 4, which in turn are easily obtained from 1:2 condensation of anilines 1 with diethyl malonate 2a or 1:1 condensation of diethyl alkyl- or arylmalonates 2b-e with 4-hydroxy-2(1H)-quinolones 3. Nitropyranoquinolinediones 6 furnish after ringopening 3-nitroacetyl-4-hydroxy-2(1H)quinolones 8. Pyranoquinolines 7 and 9 with acetyl- or aminosubstituents are hydrolyzed during basic ringopening to yield 5.

  DOI：

  10.1002/prac.19943360707

文献信息

• Mazzei; Roma; Ermili, Farmaco, Edizione Scientifica, 1979, vol. 34, # 6, p. 469 - 477
  作者：Mazzei、Roma、Ermili、Cacciatore

  DOI：——

  日期：——
• MAZZEI M.; ROMA G.; ERMILI A.; CACCIATORE C., FARMACO. ED. SCI., 1979, 34, NO 6, 469-477
  作者：MAZZEI M.、 ROMA G.、 ERMILI A.、 CACCIATORE C.

  DOI：——

  日期：——