racem.-2,3-dibenzyl-succinic acid-anhydride | 101723-61-9

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 呋喃类木脂素
• 英文名称: racem.-2,3-dibenzyl-succinic acid-anhydride
• 英文别名: racem.-2,3-Dibenzyl-bernsteinsaeure-anhydrid；(2S,3S)-2,3-dibenzylsuccinic anhydride；(3S,4S)-3,4-dibenzyloxolane-2,5-dione
• CAS: 101723-61-9；126965-29-5
• 化学式: C₁₈H₁₆O₃
• 分子量: 280.323
• InChiKey: RKWQVULIHTWYPJ-HOTGVXAUSA-N

物化性质

• 熔点：
  74-75 °C(Solv: ligroine (8032-32-4))
• 沸点：
  458.8±14.0 °C(Predicted)
• 密度：
  1.222±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  racem.-2,3-dibenzyl-succinic acid-anhydride 在 sodium carbonate 作用下， 生成 racem.-2,3-dibenzyl-succinic acid
  参考文献：
  名称：

  Cordier, Annales de Chimie (Cachan, France), 1931, vol. <10> 15, p. 228,298, 301

  摘要：

  DOI：
• 作为产物：
  描述：

  meso-1,2-bisbenzylethane-1,2-dicarboxylic acid 在 乙酸酐 作用下， 生成 racem.-2,3-dibenzyl-succinic acid-anhydride
  参考文献：
  名称：

  Cordier, Annales de Chimie (Cachan, France), 1931, vol. <10> 15, p. 228,298, 301

  摘要：

  DOI：

文献信息

• Metallo-beta-lactamase inhibitors
  申请人：Chikauchi Ken

  公开号：US20080090825A1

  公开（公告）日：2008-04-17

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  一种新的金属β-内酰胺酶抑制剂，作为一种药物用于抑制β-内酰胺类抗生素的失活并恢复抗菌活性。具有一般式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将一般式（I）的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生细菌对β-内酰胺类抗生素的抗菌活性。
• METALLO-BETA-LACTAMASE INHIBITORS
  申请人：Chikauchi Ken

  公开号：US20120071457A1

  公开（公告）日：2012-03-22

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  本发明揭示了一种新型金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复其抗菌活性。具有通式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。将通式（I）化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。
• Metallo-β-lactamase inhibitors
  申请人：Chikauchi Ken

  公开号：US09260375B2

  公开（公告）日：2016-02-16

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  本发明揭示了一种新的金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复抗菌活性。具有一般式（I）的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将一般式（I）的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。
• METALLO-B-LACTAMASE INHIBITORS
  申请人：MEIJI SEIKA KAISHA, LTD.

  公开号：US20160151322A1

  公开（公告）日：2016-06-02

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  揭示了一种新的金属β-内酰胺酶抑制剂，可作为药物用于抑制β-内酰胺类抗生素的失活并恢复其抗菌活性。具有通式(I)的马来酸衍生物具有金属β-内酰胺酶抑制活性。通过将通式(I)的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺酶产生的细菌对β-内酰胺类抗生素的抗菌活性。
• METALLO-BETA-LACTAMASE INHIBITOR
  申请人：Meiji Seika Kaisha, Ltd.

  公开号：EP1941873A1

  公开（公告）日：2008-07-09

  A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.

  本发明公开了一种新的金属-β-内酰胺酶抑制剂，它可作为一种抑制β-内酰胺类抗生素失活并恢复抗菌活性的药物。具有通式（I）的马来酸衍生物具有金属-β-内酰胺酶抑制活性。通过将通式（I）的化合物与β-内酰胺类抗生素结合，可以恢复β-内酰胺类抗生素对产生金属-β-内酰胺酶的细菌的抗菌活性。