| 142924-78-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 142924-78-5
• 化学式: C₆H₁₀ClN₃O*C₁₀H₁₆O₄S*ClH
• 分子量: 444.379
• InChiKey: MXMYTKCLARWZCW-QJUNUNGNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  27.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  146.37
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  D(+)-10-樟脑磺酸 、 以 水 为溶剂， 以17 mg的产率得到dicamphosulfonate de desaminogirolline
  参考文献：
  名称：

  Synthèse stéréosélective de la girolline

  摘要：

  Desaminogirollines syn 2'S,3'S and 2'R,3'R have been prepared from N1-camphosulfonamide 4-carboxaldehyde imidazole and their diastereoisomeric derivatives have been separated. The stereoselective synthesis of chiral natural girolline has been achieved from D(-)arabinose: this ose is condensed with formamidine acetate to obtain a 4(5)-[1',2',3'-trihydroxypropyl]-imidazole; the side-chain is chlorinated before being aminated via an azido compound and the 2-amino group of girolline is obtained by rhodium catalytic reduction of the 2-diazo derivative.

  DOI：

  10.1016/s0040-4020(01)80443-9
• 作为产物：
  描述：

  (1R,4S)-1,7,7-Trimethyl-3-oxo-2-oxa-bicyclo[2.2.1]heptane-4-carboxylic acid (1S,2S)-3-tert-butoxycarbonylamino-2-chloro-1-[1-((1S,4R)-7,7-dimethyl-2-oxo-bicyclo[2.2.1]hept-1-ylmethanesulfonyl)-1H-imidazol-4-yl]-propyl ester 在 盐酸 作用下， 反应 24.0h， 以25 mg的产率得到
  参考文献：
  名称：

  Synthèse stéréosélective de la girolline

  摘要：

  Desaminogirollines syn 2'S,3'S and 2'R,3'R have been prepared from N1-camphosulfonamide 4-carboxaldehyde imidazole and their diastereoisomeric derivatives have been separated. The stereoselective synthesis of chiral natural girolline has been achieved from D(-)arabinose: this ose is condensed with formamidine acetate to obtain a 4(5)-[1',2',3'-trihydroxypropyl]-imidazole; the side-chain is chlorinated before being aminated via an azido compound and the 2-amino group of girolline is obtained by rhodium catalytic reduction of the 2-diazo derivative.

  DOI：

  10.1016/s0040-4020(01)80443-9