ethyl-7′-amino-1′,2′,3′,4′-tetrahydro-1,2′,3,4′-tetraoxospiro[indene-2,5′-[4′H]pyrano[2,3-d]pyrimidine]-6′-carboxylate | 1380401-48-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: ethyl-7′-amino-1′,2′,3′,4′-tetrahydro-1,2′,3,4′-tetraoxospiro[indene-2,5′-[4′H]pyrano[2,3-d]pyrimidine]-6′-carboxylate
• 英文别名: ethyl 7'-amino-1,2',3,4'-tetraoxo-1,1',2',3,3',4'-hexahydrospiro[indene-2,5'-pyrano[2,3-d]pyrimidine]-6'-carboxylate；ethyl-7'-amino-1,2',3,4'-tetraoxo-1,1',2',3,3',4'-hexahydrospiro[indene-2,5'-pyrano[2,3-d]pyrimidine]-6'-carboxylate
• CAS: 1380401-48-8
• 化学式: C₁₈H₁₃N₃O₇
• 分子量: 383.317
• InChiKey: XLGDLQVTMJTJET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.49
• 重原子数：
  28.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  161.41
• 氢给体数：
  3.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  巴比妥酸 、 1,2,3-茚满三酮 、 氰乙酸乙酯 在 β-环糊精 作用下， 以 水 为溶剂， 反应 5.0h， 以90%的产率得到ethyl-7′-amino-1′,2′,3′,4′-tetrahydro-1,2′,3,4′-tetraoxospiro[indene-2,5′-[4′H]pyrano[2,3-d]pyrimidine]-6′-carboxylate
  参考文献：
  名称：

  One-pot synthesis of tetrahydro-4H-chromenes by supramolecular catalysis in water

  摘要：

  四氢-4H-色酮通过β-环糊精在水中进行高效一锅三组分协同催化合成。

  DOI：

  10.1039/c5ra14385c

文献信息

• Glycerol as a biodegradable and reusable promoting medium for the catalyst-free one-pot three component synthesis of 4H-pyrans
  作者：Hamid Reza Safaei、Mohsen Shekouhy、Sudabeh Rahmanpur、Athar Shirinfeshan

  DOI：10.1039/c2gc35135h

  日期：——

  Glycerol is applied as a green, biodegradable and reusable promoting medium for one-pot three component synthesis of 4H-pyrans under catalyst-free conditions. A broad range of substrates including aromatic and heteroaromatic aldehydes, isatine derivatives, acenaphthenequinone and ninehydrine are condensed with carbonyl compounds possessing a reactive α-methylene group and alkylmalonates. All reactions are completed in short times, and the products are obtained in good to excellent yields. The reaction medium could be recycled and reused several times without any loss of efficiency.

  甘油作为绿色、生物可降解且可重复利用的促进介质，在无催化剂条件下用于一锅法三组分合成4H-吡喃。广泛的一系列底物，包括芳香和杂环醛、吲哚醌衍生物、苊醌和九氢吲哚，与具有活性α-亚甲基的羰基化合物及烷基丙二酸酯进行缩合反应。所有反应均在短时间内完成，产物收率良好至优异。反应介质可回收并重复使用多次，效率无任何损失。
• Polystyrene@graphene oxide-Fe3O4 as a novel and magnetically recyclable nanocatalyst for the efficient multi-component synthesis of spiro indene derivatives
  作者：Seyedeh Fatemeh Hojati、Amirhassan Amiri、Maryam Mahamed

  DOI：10.1007/s11164-019-04021-w

  日期：2020.2

  (GO-Fe3O4) nanocomposite has been prepared and characterized by FT-IR, TEM and VSM techniques, and its catalytic activity has been evaluated in the multi-component synthesis of two series of indene derivatives. The three-component condensation of ninhydrin/isatin, malononitrile and active methylene-containing compounds and also the four-component condensation of ninhydrin, o-phenylenediamines, malononitrile

  制备了聚苯乙烯（PS）包覆的磁性氧化石墨烯（GO-Fe 3 O 4）纳米复合材料，并通过FT-IR，TEM和VSM技术对其进行了表征，并在两个系列的多组分合成中评估了其催化活性。茚衍生物。在PS @ GO-Fe存在下，令人满意地进行了茚三酮/靛红，丙二腈和含活性亚甲基的化合物的三组分缩合，以及茚三酮，邻苯二胺，丙二腈和含活性亚甲基的化合物的四组分缩合。3 O 4磁性纳米复合材料，以及相应的2'-氨基螺[indene-2,4'-吡喃] -3'-腈，2'-氨基螺[二氢吲哚-3、4'-吡喃] -3'-腈和2' -aminospiro [indeno [1,2-分别以良好至优异的产率获得了b ]喹喔啉-11,4'-吡喃] -3'-腈。与所报道的方法相比，反应时间非常短，易于后处理程序以及催化剂的易于分离和可重复使用性是当前方法的显着优势。
• Cu (II)-β-cyclodextrin complex stabilized on magnetic nanoparticles: A retrievable hybrid promoter for green synthesis of spiropyrans
  作者：Najmieh Ahadi、Mohammad Ali Bodaghifard、Akbar Mobinikhaledi

  DOI：10.1002/aoc.4738

  日期：2019.2

  the Cu (II)‐β‐CD complex was prepared. The structure of nanoparticles was characterized by Fourier transform‐infrared spectroscopy, X‐ray powder diffraction, thermogravimetric analysis, vibrating‐sample magnetometry, inductively coupled plasma‐optical emission spectrometry and scanning electron microscope analyses. The catalytic activity of these nanoparticles was investigated in the synthesis of spiropyrans

  锰铁氧体（MnFe 2 O 4）纳米粒子的磁芯与铁氧体（Fe 3 O 4）相比具有显着的稳定性）纳米粒子。β-环糊精（β-CD）的独特超分子性质，例如疏水腔，亲水性外部基团和-OH官能团，使其成为功能化和催化应用的良好候选者。因此，制备了具有Cu（II）-β-CD配合物的表面改性磁性固体载体。纳米颗粒的结构通过傅立叶变换红外光谱，X射线粉末衍射，热重分析，振动样品磁力分析，电感耦合等离子体发射光谱和扫描电子显微镜分析进行表征。在螺吡喃的合成和高收率下在绿色介质下获得所需产物的过程中，研究了这些纳米颗粒的催化活性。这种新型催化剂在该反应中的一些优点是收率高，反应时间短，
• Ionic liquid catalyzed one-pot synthesis of spiropyran derivatives via three-component reaction in water
  作者：Shuai-Shuai Jin、Mao-Hua Ding、Hong-Yun Guo

  DOI：10.1515/hc-2012-0159

  日期：2013.4.1

  Abstract The ionic liquid [H3N+CH2CH2OH][CH3COO-] (HEAA) catalyzes a three-component, one-pot condensation of malononitrile/ethyl cyanoacetate, 1,3-dicarbonyl compound/enol, and quinone or ninhydrin in water to afford a spiropyran derivative. This method has advantages of mild reaction conditions, short reaction time, and environmental friendliness.

  摘要 离子液体 [H3N+CH2CH2OH][CH3COO-] (HEAA) 催化丙二腈/氰乙酸乙酯、1,3-二羰基化合物/烯醇和醌或茚三酮在水中的三组分一锅缩合反应得到螺吡喃衍生物。该方法具有反应条件温和、反应时间短、环境友好等优点。
• The copolymer coating effect on the catalytic activity of magnetic carbon nanotube (CNT-Fe3O4) in the multi-component reactions
  作者：Seyedeh Fatemeh Hojati、Amirhassan Amiri、Elham Fardi、Maryam Mahamed

  DOI：10.1007/s11164-022-04663-3

  日期：2022.4

  magnetic carbon nano-tubes (poly(Ani-co-Py)@CNT-Fe3O4) were synthesized and characterized by Fourier transform infrared (FT-IR) spectroscopy, energy-dispersive X-ray analysis (EDS), scanning electron microscopy (SEM) and vibrating-sample magnetometer (VSM) techniques. The catalytic activity of poly(Ani-co-Py)@CNT-Fe3O4 nanocomposites was investigated in the multi-component preparation of 2′-aminospiro[indeno[1

  摘要 合成了两种含有苯胺-吡咯共聚物包覆磁性碳纳米管的新型磁性纳米复合材料（poly(Ani-co-Py)@CNT-Fe 3 O 4），并通过傅里叶变换红外（FT-IR）光谱、能量-色散 X 射线分析 (EDS)、扫描电子显微镜 (SEM) 和振动样品磁力计 (VSM) 技术。聚(Ani-co-Py)@CNT-Fe 3 O 4纳米复合材料在2′-氨基螺[茚并[1,2 - b ]喹喔啉-11,4′-[ 4' H ]吡喃]-3'-腈和 2'-氨基螺[茚并-2,4'-[4' H]吡喃]-3'-腈衍生物。还一起研究和比较了这些纳米复合材料的可重复使用性。催化剂的高效、可重复使用、无毒、稳定性和磁分离以及反应时间短、产品收率高、后处理简单、产品纯度高是目前方法的显着优点。 图形概要