反式-1-乙基-4-叔丁基环己醇 | 25143-76-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 反式-1-乙基-4-叔丁基环己醇
• 英文名称: trans-1-ethyl-4-tert-butylcyclohexanol
• 英文别名: trans-4-t-butyl-1-ethyl-1-cyclohexanol；cis-1-ethyl-4-tert-butylcyclohexanol；cis-1-ethyl-4-t-butylcyclohexanol；1-ethyl-4t-tert-butyl-cyclohexan-r-ol；1-Aethyl-4t-tert-butyl-cyclohexan-r-ol；4α-tert.-Butyl-1α-aethyl-cyclohexanol-(1β)
• CAS: 25143-76-4
• 化学式: C₁₂H₂₄O
• 分子量: 184.322
• InChiKey: ZRYBOCPSQCTIDH-UMSPYCQHSA-N

物化性质

• 沸点：
  229.3±8.0 °C(Predicted)
• 密度：
  0.896±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.36
• 重原子数：
  13.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  (1r,4r)-4-(tert-butyl)-1-ethynylcyclohexan-1-ol 在 乙醇 、 镍 作用下， 生成 反式-1-乙基-4-叔丁基环己醇
  参考文献：
  名称：

  Ethynylation of 4-t-Butylcyclohexanone and Kinetics of Saponification of the Ethynylcarbinol Esters¹

  摘要：

  DOI：

  10.1021/ja01536a027

文献信息

• Electroreductive intermolecular coupling of ketones with O-methyl oximes. A convenient route to synthesis of 2-amino alcohols
  作者：Tatsuya Shono、Naoki Kise、Taku Fujimoto

  DOI：10.1016/s0040-4039(00)79486-x

  日期：1991.1

  The electroreduction of ketones together with O-methyl oximes gave intermolecularly coupled products, 2-methoxyamino alcohols, which were easily reduced to 2-amino alcohols.

  酮与O-甲基肟的电还原得到分子间偶联的产物2-甲氧基氨基醇，该产物容易还原为2-氨基醇。
• Organometallic reaction mechanisms
  作者：E.C. Ashby、R. Scott Smith

  DOI：10.1016/s0022-328x(00)86812-6

  日期：1982.2

  compared to the reactions of triethylaluminium with the same ketone. The results support the importance of a bridging alkyl group described by the formation of a six-centered transition state when two equivalents of a trialkylaluminum compound are allowed to react with a ketone in hydrocarbon solvent. The results also argue against a transition state described by two moles of trialkylaluminum compound complexed

  等2 ALCH 2 ALET 2（1）已被用来作为一种机械探针，以确定在三烷基铝化合物的两个当量的在烃溶剂中的酮该反应的过渡态的性质。在苯中制备1，并确定溶液组成。低温1个的1 H NMR数据1作为单（乙醚化物）表明醚氧被同时配位到两个铝原子上。1的反应将4-叔丁基环己酮在烃类溶剂中的含量与三乙基铝与相同酮的反应进行了比较。当在烃类溶剂中使两当量的三烷基铝化合物与酮反应时，结果支持形成六中心过渡态所描述的桥接烷基的重要性。该结果还反对了由两摩尔与羰基氧原子络合的三烷基铝化合物描述的过渡态。
• Amphiphilic reactions by means of exceptionally bulky organoaluminum reagents. Rational approach for obtaining unusual equatorial, anti-Cram, and 1,4 selectivity in carbonyl alkylation
  作者：Keiji. Maruoka、Takayuki. Itoh、Minoru. Sakurai、Katsumasa. Nonoshita、Hisashi. Yamamoto

  DOI：10.1021/ja00219a038

  日期：1988.5
• Electroorganic chemistry. 140. Electroreductively promoted intra- and intermolecular couplings of ketones with nitriles.
  作者：Tatsuya Shono、Naoki Kise、Taku Fujimoto、Naoto Tominaga、Hiroshi Morita

  DOI：10.1021/jo00052a036

  日期：1992.12

  Electroreduction of gamma and delta-cyano ketones in i-PrOH with Sn cathode gave alpha-hydroxy ketones and their dehydroxylated ketones as the intramolecularly coupled products. Guaiazulene, (-)-valeranone, polyquinanes, dihydrojasmone, methyl dihydrojasmonate, and rosaprostol have been synthesized by utilizing this electroreductive intramolecular coupling of gamma and delta-cyano ketones in one of the key steps. Similarly, electroreduction of a mixture of ketone and nitrile gave the corresponding intermolecularly coupled product. The product obtained by the electroreductive intermolecular coupling of (+)-dihydrocarvone with acetonitrile has been found to be the precursor of an effective chiral ligand for the enantioselective addition of diethylzinc to aldehydes.
• Synthesis of 2,2-disubstituted oxetanes from ketones with S-methyl-S-(sodiomethyl)-N-(4-tolylsulfonyl)sulfoximine
  作者：Steven C. Welch、A. S. C. Prakasa Rao、John T. Lyon、Jean Marie Assercq

  DOI：10.1021/ja00340a019

  日期：1983.1