(2R,2'R,3R,3'R)-6,6,6',6'-tetramethyloctahydro-2H,2'H-[2,2'-bipyran]-3,3'-diyl dibenzoate | 394739-02-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,2'R,3R,3'R)-6,6,6',6'-tetramethyloctahydro-2H,2'H-[2,2'-bipyran]-3,3'-diyl dibenzoate
• CAS: 394739-02-7
• 化学式: C₂₈H₃₄O₆
• 分子量: 466.574
• InChiKey: HREXFLPZYUVXGX-MOUTVQLLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.35
• 重原子数：
  34.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  71.06
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (2R,2'R,3R,3'R)-6,6,6',6'-tetramethyloctahydro-2H,2'H-[2,2'-bipyran]-3,3'-diyl dibenzoate 在 氢氧化钾 、 水 作用下， 以89%的产率得到(2R,3R,2'R,3'R)-6,6,6',6'-Tetramethyl-octahydro-[2,2']bipyranyl-3,3'-diol
  参考文献：
  名称：

  Pd-catalyzed asymmetric allylation with a novel C 2 -symmetric bisphosphinite ligand: 3 R ,3′ R -bis(diphenylphosphinoxy)-6,6,6′,6′-tetramethyl-2 S ,2′ S -di-4 H -pyran

  摘要：

  A novel C-2-symmetric chiral bisphosphinite ligand, 3R,3'R-bis(diphenylphosphinoxy)-6,6,6',6'-tetramethyl-2S,2'S-di-4H-pyran, was synthesized from D-mannitol and examined for palladium-catalyzed asymmetric allylic substitution. Under the optimized conditions, the allylation product can be obtained in up to 91.2% ee. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01624-0
• 作为产物：
  描述：

  (5R,6R,7R,8R)-2,11-dimethyl-5,8-bis(benzoyloxy)-6,7-isopropylidenedioxydodeca-1,11-diene 在 高氯酸 、 水 作用下， 以100%的产率得到(2R,2'R,3R,3'R)-6,6,6',6'-tetramethyloctahydro-2H,2'H-[2,2'-bipyran]-3,3'-diyl dibenzoate
  参考文献：
  名称：

  Pd-catalyzed asymmetric allylation with a novel C 2 -symmetric bisphosphinite ligand: 3 R ,3′ R -bis(diphenylphosphinoxy)-6,6,6′,6′-tetramethyl-2 S ,2′ S -di-4 H -pyran

  摘要：

  A novel C-2-symmetric chiral bisphosphinite ligand, 3R,3'R-bis(diphenylphosphinoxy)-6,6,6',6'-tetramethyl-2S,2'S-di-4H-pyran, was synthesized from D-mannitol and examined for palladium-catalyzed asymmetric allylic substitution. Under the optimized conditions, the allylation product can be obtained in up to 91.2% ee. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01624-0