(S)-2-chloro-1-(2-ethyl-8-methoxyquinolin-5-yl)propan-1-one | 1421045-80-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (S)-2-chloro-1-(2-ethyl-8-methoxyquinolin-5-yl)propan-1-one
• CAS: 1421045-80-8
• 化学式: C₁₅H₁₆ClNO₂
• 分子量: 277.751
• InChiKey: DJDKLIRDUXVIHR-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.62
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  39.19
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (S)-2-chloro-1-(2-ethyl-8-methoxyquinolin-5-yl)propan-1-one 在 palladium 10% on activated carbon 、 氢气 、 sodium hydride 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  A mild and efficient synthesis of a chiral pyridazinone derivative

  摘要：

  We found a mild and efficient reaction condition for construction of a chiral 5-methyl-4,5-dihydropyridazin-3(2H)-one from a chiral beta-methyl gamma-ketocarboxylic acid via the corresponding acid hydrazide without racemization. Furthermore, we demonstrated that this two-step reaction can be attained by one-pot reaction. This method could be applied to various kinds of substrates because of the mild reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.11.072
• 作为产物：
  描述：

  2-氯丙酰氯 、 2-ethyl-8-methoxyquinoline 以 硝基甲烷 为溶剂， 反应 5.0h， 以34%的产率得到(S)-2-chloro-1-(2-ethyl-8-methoxyquinolin-5-yl)propan-1-one
  参考文献：
  名称：

  A mild and efficient synthesis of a chiral pyridazinone derivative

  摘要：

  We found a mild and efficient reaction condition for construction of a chiral 5-methyl-4,5-dihydropyridazin-3(2H)-one from a chiral beta-methyl gamma-ketocarboxylic acid via the corresponding acid hydrazide without racemization. Furthermore, we demonstrated that this two-step reaction can be attained by one-pot reaction. This method could be applied to various kinds of substrates because of the mild reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.11.072