(2-chloro-1,4-phenylene)bis(oxy)bis(methylene)dibenzene | 1258381-48-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2-chloro-1,4-phenylene)bis(oxy)bis(methylene)dibenzene
• 英文别名: 2-chloro-1,4-dibenzyloxybenzene；2-Chloro-1,4-bis(phenylmethoxy)benzene
• CAS: 1258381-48-4
• 化学式: C₂₀H₁₇ClO₂
• 分子量: 324.807
• InChiKey: RIEHOILSRRJJLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-chloro-1,4-phenylene)bis(oxy)bis(methylene)dibenzene 在 N-氯代丁二酰亚胺 、 偶氮二甲酸二异丙酯 、 (2-methylpropyl)lithium 、 三苯基膦 、 zinc(II) chloride 作用下， 以 四氢呋喃 、 二氯甲烷 、 环己烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 50.75h， 生成 ((5,8-bisbenzyloxy-2-chloro-4-3S,4R,5R,6R-3,4,5-trisbenzyloxy-6-benzyloxymethyltetrahydro-2H-pyran-2-ylnaphthalen-1-yloxy)methyl)4-tert-butyldimethylsilyloxymethyl-5-(methylthio)furan-2-yldimethylsilane
  参考文献：
  名称：

  Approach Toward the Total Synthesis of 5-Hydroxyaloin A

  摘要：

  The synthesis of a thiomethyl analogue of 5-hydroxyaloin A has been achieved using benzyne and naphthyne [4 + 2] cycloadditions with substituted furans. A regiocontrolled cycloaddition was achieved using a silicon tether, and a regioselective ring opening was accomplished using a sulfide as a directing group.

  DOI：

  10.1021/ol102318k
• 作为产物：
  描述：

  溴甲苯 、 氯氢醌 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 以65%的产率得到(2-chloro-1,4-phenylene)bis(oxy)bis(methylene)dibenzene
  参考文献：
  名称：

  Asymmetric Synthesis of α-Aryl Amino Acids; Aryne-Mediated Diastereoselective Arylation

  摘要：

  An aryne-mediated alpha-arylation reaction of Schollkopf's bis-lactim ether is described. Arynes were generated via an ortho-lithiation approach, affording syn-arylated products in up to 94:6 dr with moderate to good yields and excellent regioselectivities. Hydrolysis provided a variety of substituted arylglycines containing a range of functional groups without racemization.

  DOI：

  10.1021/ol1030469

文献信息

• ULTRAVIOLET CURABLE LIQUID COMPOSITION, ULTRAVIOLET CURING INKJET INK, ULTRAVIOLET CURING WET ELECTROPHOTOGRAPHIC LIQUID DEVELOPER, ULTRAVIOLET CURING ELECTROSTATIC INKJET INK, AND IMAGE FORMING METHOD USING THEREOF
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20170336728A1

  公开（公告）日：2017-11-23

  An object of the present invention is to provide an ultraviolet curing liquid composition having high sensitivity, excellent storage stability, low viscosity, and excellent fixability after ultraviolet curing. The ultraviolet curable liquid composition of the present invention is an ultraviolet curable liquid composition containing a cationically polymerizable liquid monomer, a photopolymerization initiator and a photopolymerization sensitizer, wherein the cationically polymerizable liquid monomer is a vinyl ether compound, the photopolymerization initiator includes a compound represented by general formula (1), and the photopolymerization sensitizer includes (A) at least one compound selected from the group consisting of a compound represented by general formula (2) and a compound represented by general formula (3), and (B) at least one compound selected from the group consisting of a compound represented by general formula (4) and a compound represented by general formula (5).
• [EN] 2-AMINOHYDROQUINONE DERIVATIVE AND TAU AGGREGATION INHIBITOR<br/>[FR] DÉRIVÉ DE 2-AMINOHYDROQUINONE ET INHIBITEUR D'AGRÉGATION DE TAU<br/>[JA] ２－アミノヒドロキノン誘導体及びタウ凝集阻害剤
  申请人：DOSHISHA

  公开号：WO2016051799A1

  公开（公告）日：2016-04-07

  　細胞内のタウ凝集を十分に抑制できるタウ凝集阻害剤を提供する。下記式（Ｉ）からなる化合物又はその塩である。この化合物は、タウオパチーの治療、診断、症状の軽減及び予防からなる群から選択される少なくとも一つの用途に使用される。
• Asymmetric Synthesis of α-Aryl Amino Acids; Aryne-Mediated Diastereoselective Arylation
  作者：Elizabeth P. Jones、Peter Jones、Anthony G. M. Barrett

  DOI：10.1021/ol1030469

  日期：2011.3.4

  An aryne-mediated alpha-arylation reaction of Schollkopf's bis-lactim ether is described. Arynes were generated via an ortho-lithiation approach, affording syn-arylated products in up to 94:6 dr with moderate to good yields and excellent regioselectivities. Hydrolysis provided a variety of substituted arylglycines containing a range of functional groups without racemization.
• Approach Toward the Total Synthesis of 5-Hydroxyaloin A
  作者：Kristen J. Procko、Hui Li、Stephen F. Martin

  DOI：10.1021/ol102318k

  日期：2010.12.17

  The synthesis of a thiomethyl analogue of 5-hydroxyaloin A has been achieved using benzyne and naphthyne [4 + 2] cycloadditions with substituted furans. A regiocontrolled cycloaddition was achieved using a silicon tether, and a regioselective ring opening was accomplished using a sulfide as a directing group.