α-methoxy-1,4-di-isopropylbenzene | 145674-63-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: α-methoxy-1,4-di-isopropylbenzene
• 英文别名: 1-(2-Methoxypropan-2-yl)-4-propan-2-ylbenzene
• CAS: 145674-63-1
• 化学式: C₁₃H₂₀O
• 分子量: 192.301
• InChiKey: OJPJBMYYEANCAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  甲醇 、 1,4-二异丙基苯 在 sodium methylate 作用下， 反应 1.5h， 以24%的产率得到α,α'-dimethoxy-1,4-di-isopropylbenzene
  参考文献：
  名称：

  Anodic oxidation of isopropyl and tert-butylbenzenes. Synthetic routes to certain cyclohexa-1,4-dienes

  摘要：

  DOI：

  10.1016/s0040-4020(01)92286-0

文献信息

• TANK-BINDING KINASE INHIBITOR COMPOUNDS
  申请人：Du Zhimin

  公开号：US20150344473A1

  公开（公告）日：2015-12-03

  Compounds having the following formula (I) and methods of their use and preparation are disclosed:

  公开具有以下式（I）的化合物及其使用和制备方法：
• High-strength low-creep thermoplastic elastomer
  申请人：Kennedy Joseph

  公开号：US10626207B1

  公开（公告）日：2020-04-21

  A polystyrene-g-(polyisobutylene-b-polystyrene) is taught. The polystyrene-g-(polyisobutylene-b-polystyrene) is synthesized by first providing a polystyrene backbone. Once the polystyrene backbone is provided, the polystyrene backbone is acetylated to provide acetyl groups on the polystyrene backbone. Next, the acetyl groups are converted to —C(CH3)2OH groups. Finally, the living polymerization of isobutylene is initiated, which is then followed by the living block polymerization of styrene. A polymer network of polystyrene-g-(polyisobutylene-b-polystyrene)s is also provided.

  本发明涉及一种聚苯乙烯-g-（聚异丁烯-b-聚苯乙烯）。聚苯乙烯-g-（聚异丁烯-b-聚苯乙烯）的合成首先要提供聚苯乙烯骨架。提供聚苯乙烯主链后，对聚苯乙烯主链进行乙酰化，在聚苯乙烯主链上提供乙酰基。接着，乙酰基转化为-C(CH3)2OH 基团。最后，异丁烯开始活聚合，接着苯乙烯开始活嵌段聚合。此外，还提供了一种聚苯乙烯-g-（聚异丁烯-b-聚苯乙烯）的聚合物网络。
• Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
  申请人：Shy Therapeutics LLC

  公开号：US11000515B2

  公开（公告）日：2021-05-11

  Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.

  本文提供了通过化合物与 Ras 超家族蛋白（在某些情况下包括 K-Ras 及其突变体）的 GTP 结合结构域结合，治疗涉及 Ras 超家族信号异常的癌症、炎症性疾病、rasopathies 和纤维化疾病的方法和组合物，以及检测此类组合物的新方法。
• Pyrrolo[2,3-C]pyridines and related analogs as LSD-1 inhibitors
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US11168082B2

  公开（公告）日：2021-11-09

  The present disclosure provides compounds represented by Formula I and II: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, X, W, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I and II for use to treat a condition or disorder responsive to LSD1 inhibition such as cancer.

  本公开提供了式 I 和 II 所代表的化合物：及其药学上可接受的盐和溶液，其中 R1、R2、R3、X、W、Y 和 Z 如说明书中所定义。本公开还提供了式 I 和 II 的化合物，用于治疗对 LSD1 抑制有反应的病症或紊乱，如癌症。
• COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE
  申请人：Shy Therapeutics LLC

  公开号：US20200061037A1

  公开（公告）日：2020-02-27

  Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.