C-(6,6-Dimethyl-bicyclo[3.1.1]hept-1-yl)-methylamine | 146070-97-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: C-(6,6-Dimethyl-bicyclo[3.1.1]hept-1-yl)-methylamine
• 英文别名: (6,6-Dimethyl-1-bicyclo[3.1.1]heptanyl)methanamine
• CAS: 146070-97-5
• 化学式: C₁₀H₁₉N
• 分子量: 153.268
• InChiKey: UJPZNALZLHGYPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  C-(6,6-Dimethyl-bicyclo[3.1.1]hept-1-yl)-methylamine 在 lithium aluminium tetrahydride 作用下， 以 乙醚 、 萘烷 为溶剂， 反应 20.0h， 生成 3-(6,6-Dimethyl-bicyclo[3.1.1]hept-1-ylmethyl)-2,3,5,6,7,8-hexahydro-1H-benzo[4,5]thieno[2,3-d]pyrimidin-4-one
  参考文献：
  名称：

  Gravier; Hou; Casadebaig, Pharmazie, 1992, vol. 47, # 10, p. 754 - 757

  摘要：

  DOI：

文献信息

• Medicinal Composition for Inhalation
  申请人：Yamamoto Shigeki

  公开号：US20080114043A1

  公开（公告）日：2008-05-15

  A medicinal composition for inhalation containing a continuous-release type prodrug of an EP2 agonist topically exhibits a prolonged bronchodilating and antiinflammatory effects. Namely, the medicinal composition for inhalation containing a continuous-release type prodrug of an EP2 agonist is useful as a safe preventive and/or a remedy for respiratory diseases (for example, asthma, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, adult respiratory distress syndrome, cystic fibrosis, pulmonary hypertension or the like) without causing any systemic effect such as lowering blood pressure. Thus, a safe and useful remedy for respiratory diseases is provided.

  一种含有EP2激动剂的持续释放型前药的吸入药物组合物，局部表现出持续的支气管扩张和抗炎作用。换言之，含有EP2激动剂的持续释放型前药的吸入药物组合物可作为安全的预防和/或治疗呼吸系统疾病（例如哮喘、肺损伤、肺纤维化、肺气肿、支气管炎、慢性阻塞性肺病、成人呼吸窘迫综合征、囊性纤维化、肺动脉高压等），而不会引起任何降低血压等全身作用。因此，提供了一种安全有效的呼吸系统疾病治疗药物。
• Novel Blt2-Mediated Disease, Blt2 Binding Agent And the Compound
  申请人：Nakade Shinji

  公开号：US20080132574A1

  公开（公告）日：2008-06-05

  [PROBLEM] The compound that selectively binds to BLT2 and the preventive and/or therapeutic drug for BLT2-mediated disease such as skin disease are needed. [MEANS FOR SOLVING THE PROBLEMS] The present invention provides the compound with BLT2 binding activity, salt thereof, solvate thereof or prodrug thereof. Since the compound with BLT2 binding activity, particularly the compound represented by the formula (I) salt thereof, solvate thereof or prodrug thereof (symbols in formula have the same meanings as specification.) have BLT2 binding activity, it is useful for prevention and/or therapy of BLT2 mediated diseases, e.g., dermatosis, intestinal disease, HIV infection, acquired immunodeficiency syndrome, rejection to transplant, transplant rejection, graft-versus-host disease, autoimmune disease, allergic disease, inflammation, infection, ulcers, lymphoma, malignant tumor, leucaemia, arterial sclerosis, hepatitis, hepatic cirrhosis or cancer, etc.

  【问题】需要一种选择性结合于BLT2的化合物和预防和/或治疗BLT2介导的疾病，如皮肤病的药物。 【解决方法】本发明提供具有BLT2结合活性的化合物，其盐，溶剂化物或前药。由于具有BLT2结合活性的化合物，特别是由式（I）表示的化合物，其盐，溶剂化物或前药（式中的符号与说明书具有相同的含义）具有BLT2结合活性，因此对于预防和/或治疗BLT2介导的疾病，例如皮肤病，肠道疾病，HIV感染，获得性免疫缺陷综合症，移植排斥，移植物排斥，移植物抗宿主病，自身免疫性疾病，过敏性疾病，炎症，感染，溃疡，淋巴瘤，恶性肿瘤，白血病，动脉硬化，肝炎，肝硬化或癌症等具有用处。
• NOVEL BLT2-MEDIATED DISEASE, AND BLT2 BINDING AGENT AND COMPOUND
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1745800A1

  公开（公告）日：2007-01-24

  [PROBLEM] The compound that selectively binds to BLT2 and the preventive and/or therapeutic drug for BLT2-mediated disease such as skin disease are needed. [MEANS FOR SOLVING THE PROBLEMS] The present invention provides the compound with BLT2 binding activity, salt thereof, solvate thereof or prodrug thereof. Since the compound with BLT2 binding activity, particularly the compound represented by the formula (I) , salt thereof, solvate thereof or prodrug thereof (symbols in formula have the same meanings as specification.) have BLT2 binding activity, it is useful for prevention and/or therapy of BLT2 mediated diseases, e.g., dermatosis, intestinal disease, HIV infection, acquired immunodeficiency syndrome, rejection to transplant, transplant rejection, graft-versus-host disease, autoimmune disease, allergic disease, inflammation, infection, ulcers, lymphoma, malignant tumor, leucaemia, arterial sclerosis, hepatitis, hepatic cirrhosis or cancer, etc.

  [问题]需要选择性结合 BLT2 的化合物和 BLT2 介导的疾病如皮肤病的预防和/或治疗药物。 [解决问题的方法】本发明提供了具有 BLT2 结合活性的化合物、其盐、其溶液或其原药。由于具有 BLT2 结合活性的化合物，特别是由式（I）代表的化合物 式中的符号含义与说明书相同）具有 BLT2 结合活性，因此可用于预防和/或治疗 BLT2 介导的疾病，例如：皮肤病、肠道疾病、溃疡病、溃疡性结肠炎、溃疡性结肠炎、溃疡性结肠炎、溃疡性结肠炎、溃疡性结肠炎、溃疡性结肠炎、溃疡性结肠炎等、皮肤病、肠道疾病、艾滋病病毒感染、获得性免疫缺陷综合征、移植排斥、移植排斥、移植物抗宿主疾病、自身免疫性疾病、过敏性疾病、炎症、感染、溃疡、淋巴瘤、恶性肿瘤、白血病、动脉硬化、肝炎、肝硬化或癌症等。
• MEDICINAL COMPOSITION FOR INHALATION
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1806148A1

  公开（公告）日：2007-07-11

  A medicinal composition for inhalation containing a continuous-release type prodrug of an EP2 agonist topically exhibits a prolonged bronchodilating and antiinflammatory effects. Namely, the medicinal composition for inhalation containing a continuous-release type prodrug of an EP2 agonist is useful as a safe preventive and/or a remedy for respiratory diseases (for example, asthma, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, adult respiratory distress syndrome, cystic fibrosis, pulmonary hypertension or the like) without causing any systemic effect such as lowering blood pressure. Thus, a safe and useful remedy for respiratory diseases is provided.

  一种吸入用药物组合物含有一种 EP2 激动剂的持续释放型原药，局部使用后具有延长支气管扩张和抗炎作用。也就是说，含有 EP2 激动剂持续释放型原药的吸入用药物组合物可作为呼吸系统疾病（例如哮喘、肺损伤、肺纤维化、肺气肿、支气管炎、慢性阻塞性肺病、成人呼吸窘迫综合征、囊性纤维化、肺动脉高压或类似疾病）的安全预防和/或治疗药物，而不会引起任何全身效应，例如降低血压。因此，我们提供了一种安全有用的治疗呼吸系统疾病的药物。
• Novel BLT2-mediated disease, BLT2-binding agent and compound
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP2172222A2

  公开（公告）日：2010-04-07

  [PROBLEM] The compound that selectively binds to BLT2 and the preventive and/or therapeutic drug for BLT2-mediated disease such as skin disease are needed. [MEANS] FOR SOLVING THE PROBLEMS] The present invention provides the compound with BLT2 binding activity, salt thereof, solvate thereof or prodrug thereof. Since the compound with BLT2 binding activity, particularly the compound represented by the formula (I) , salt thereof, solvate thereof or prodrug thereof (symbols in formula have the same meanings as specification.) have BLT2 binding activity, it is useful for prevention and/or therapy of BLT2 mediated diseases, e.g., dermatosis, intestinal disease, HIV infection, acquired immunodeficiency syndrome, rejection to transplant, transplant rejection, graft-versus-host disease, autoimmune disease, allergic disease, inflammation, infection, ulcers, lymphoma, malignant tumor, leucaemia, arterial sclerosis, hepatitis, hepatic cirrhosis or cancer, etc.

  [问题] 需要能选择性地与 BLT2 结合的化合物以及预防和/或治疗 BLT2 介导的疾病 （如皮肤病）的药物。 [解决问题的方法］本发明提供了具有 BLT2 结合活性的化合物、其盐、其溶液或其原药。由于具有 BLT2 结合活性的化合物，特别是式 (I) 所代表的化合物 式中的符号含义与说明书相同）具有 BLT2 结合活性，因此可用于预防和/或治疗 BLT2 介导的疾病，例如：皮肤病、肠道疾病、溃疡病、溃疡性结肠炎、溃疡性结肠炎、溃疡性结肠炎、溃疡性结肠炎、溃疡性结肠炎、溃疡性结肠炎、溃疡性结肠炎等、皮肤病、肠道疾病、艾滋病病毒感染、获得性免疫缺陷综合征、移植排斥、移植排斥、移植物抗宿主疾病、自身免疫性疾病、过敏性疾病、炎症、感染、溃疡、淋巴瘤、恶性肿瘤、白血病、动脉硬化、肝炎、肝硬化或癌症等。