2,2-Dimethyl-6-(3-oxobutyl)-1,3-dioxin-4-one | 130473-39-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-Dimethyl-6-(3-oxobutyl)-1,3-dioxin-4-one
• 英文别名: 2,2-Dimethyl-6-(3-oxobutyl)-4H-1,3-dioxin-4-one
• CAS: 130473-39-1
• 化学式: C₁₀H₁₄O₄
• 分子量: 198.219
• InChiKey: QQTCOYVGHQUSDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-6-(3-oxobutyl)-1,3-dioxin-4-one 在 咪唑 、 蔗糖 作用下， 以 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 48.0h， 生成 methyl (6S)-6-[tert-butyl(dimethyl)silyl]oxy-3-oxoheptanoate
  参考文献：
  名称：

  Synthesis of 1,3-dioxin-4-ones having chiral hydroxyalkyl groups at the 6-position by means of baker's yeast reduction and their uses for epc synthesis

  摘要：

  Prochiral methyl ketones connected with 6-(4-oxo-1,3-dioxinyl) group directly or through methylene chain (1-3) gave, by treatment with fermenting baker's yeast, the corresponding (S)-alcohols which served as synthons for a variety of enantiomerically pure compounds.

  DOI：

  10.1016/s0040-4020(01)86552-2
• 作为产物：
  描述：

  6-bromomethyl-2,2-dimethyl-4H-1,3-dioxin-4-one 在 氢气 作用下， 生成 2,2-Dimethyl-6-(3-oxobutyl)-1,3-dioxin-4-one
  参考文献：
  名称：

  Baker’s Yeast Mediated Bioreduction of Prochiral Ketones Having 6-(4-Oxo-1,3-dioxinyl) Group

  摘要：

  通过发酵酵母的方式，具有6-(4-氧代-1,3-二噁烯基)基团作为一个末端单元的拟手性酮类化合物得到了手性醇，这些手性醇可以转化为光学活性的羟基酯、β-酮酯和内酯。

  DOI：

  10.1246/cl.1990.901

文献信息

• Baker’s Yeast Mediated Bioreduction of Prochiral Ketones Having 6-(4-Oxo-1,3-dioxinyl) Group
  作者：Jun-ichi Sakaki、Miwako Suzuki、Satoshi Kobayashi、Masayuki Sato、Chikara Kaneko

  DOI：10.1246/cl.1990.901

  日期：1990.6

  Prochiral ketones having 6-(4-oxo-1,3-dioxinyl) group as one terminal unit by fermenting baker’s yeast gave chiral alcohols, which could be convertible to optically active hydroxyesters, β-ketoesters, and lactones.

  通过发酵酵母的方式，具有6-(4-氧代-1,3-二噁烯基)基团作为一个末端单元的拟手性酮类化合物得到了手性醇，这些手性醇可以转化为光学活性的羟基酯、β-酮酯和内酯。
• SAKAKI, JUN-ICHI;SUZUKI, MIWAKO;KOBAYASHI, SATOSHI;SATO, MASAYUKI;KANEKO,+, CHEM. LETT.,(1990) N, C. 901-904
  作者：SAKAKI, JUN-ICHI、SUZUKI, MIWAKO、KOBAYASHI, SATOSHI、SATO, MASAYUKI、KANEKO,+

  DOI：——

  日期：——
• Potent immunosuppressive agents derivatives and use
  申请人：Romo Daniel

  公开号：US20070149581A1

  公开（公告）日：2007-06-28

  Provided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl groups, also referred to as desmethyl, desamino-pateamine A. Suitable analogs provide anticancer and antiproliferative effects in vivo and in vitro by a novel drugs mechanism of action described herein for pateamine A, including inhibition of eIF4A-dependent translation initiation. As with pateamine A, as described herein, suitable analogs cause cell cycle arrest or induce apoptosis in transformed cells. However, toxicity of such compounds to slow growing normal cells is low. In addition, such analogs, like pateamine A, target translation initiation factors and are useful as anticancer and antiproliferative agents in subjects in need thereof. Moreover, the analogs, like pateamine A, are valuable molecular probes for evalutaion of eukaryotic translation initiation and as lead compounds for development of improved anticancer agents.
• POTENT IMMUNOSUPPRESSIVE AGENTS, DERIVATIVES AND USES
  申请人：Romo Daniel

  公开号：US20110053994A1

  公开（公告）日：2011-03-03

  Provided herein include compositions, all related stereoisomers as well as pharmaceutically acceptable salts provided as simplified analogs of pateamine A, in which the analogs generally are devoid of the C3-amino and C5-methyl groups, also referred to as desmethyl, desamino-pateamine A. Suitable analogs provide anticancer and antiproliferative effects in vivo and in vitro by a novel drugs mechanism of action described herein for pateamine A, including inhibition of eIF4A-dependent translation initiation. As with pateamine A, as described herein, suitable analogs cause cell cycle arrest or induce apoptosis in transformed cells. However, toxicity of such compounds to slow growing normal cells is low. In addition, such analogs, like pateamine A, target translation initiation factors and are useful as anticancer and antiproliferative agents in subjects in need thereof. Moreover, the analogs, like pateamine A, are valuable molecular probes for evalutaion of eukaryotic translation initiation and as lead compounds for development of improved anticancer agents.
• US7737134B2
  申请人：——

  公开号：US7737134B2

  公开（公告）日：2010-06-15