(5,10-Dioxobenzo[g]quinolin-3-yl)methyl acetate | 177158-03-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (5,10-Dioxobenzo[g]quinolin-3-yl)methyl acetate
• CAS: 177158-03-1
• 化学式: C₁₆H₁₁NO₄
• 分子量: 281.268
• InChiKey: XDDPOSDZWHBZPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  73.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (5,10-Dioxobenzo[g]quinolin-3-yl)methyl acetate 在 lithium hydroxide 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 (5,10-dioxobenzo[g]quinolin-3-yl)methyl N-propan-2-ylcarbamate
  参考文献：
  名称：

  Synthesis and in vitro evaluation of 3-substituted-1-azaanthraquinones

  摘要：

  In the course of developing novel antitumor agents, we synthesized 3-substituted-1-azaanthraquinones, incorporating the alkylating or latent alkylating substituents as potential antitumor agents. The most active comound 4 exhibited cytotoxic activity comparable to that of doxorubicin. The compounds 3-8 retained much of their activity against the doxorubicin-resistant cell line (MCF7/R). Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00156-4
• 作为产物：
  描述：

  3-methylbenzo[g]quinoline-5,10-dione 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 (5,10-Dioxobenzo[g]quinolin-3-yl)methyl acetate
  参考文献：
  名称：

  Synthesis and in vitro evaluation of 3-substituted-1-azaanthraquinones

  摘要：

  In the course of developing novel antitumor agents, we synthesized 3-substituted-1-azaanthraquinones, incorporating the alkylating or latent alkylating substituents as potential antitumor agents. The most active comound 4 exhibited cytotoxic activity comparable to that of doxorubicin. The compounds 3-8 retained much of their activity against the doxorubicin-resistant cell line (MCF7/R). Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00156-4

文献信息

• Synthesis and in vitro evaluation of 3-substituted-1-azaanthraquinones
  作者：Heesoon Lee、Seoung-Soo Hong、Young-Ho Kim

  DOI：10.1016/0960-894x(96)00156-4

  日期：1996.4

  In the course of developing novel antitumor agents, we synthesized 3-substituted-1-azaanthraquinones, incorporating the alkylating or latent alkylating substituents as potential antitumor agents. The most active comound 4 exhibited cytotoxic activity comparable to that of doxorubicin. The compounds 3-8 retained much of their activity against the doxorubicin-resistant cell line (MCF7/R). Copyright (C) 1996 Elsevier Science Ltd