毒理性
识别和使用: dibutyl phenyl phosphate是一种澄清的微黄色液体。它用于防火飞机液压油。人类暴露和毒性:接触后眼睛明显疼痛;然而,这种接触并未被报道会损害眼睛。长时间接触皮肤后,有皮肤刺激的描述。暴露于气溶胶或蒸汽会产生鼻和喉咙刺激,伴有咳嗽和喘息。动物研究:在兔子的眼睛中没有刺激,但在同一物种的重复皮肤接触时会产生皮肤刺激。在兔子和长期暴露后的大鼠中,它显著降低了血浆胆碱酯酶活性。这种化学物质没有在成年母鸡中引起有机磷化合物诱导的迟发性神经毒性(OPIDN)。在大鼠胃内给予dibutyl phenyl phosphate后,未观察到其后代有致畸或胎儿毒性效应。当在以下系统中评估时,未观察到dibutyl phenyl phosphate的诱变性:5株Salmonella和1株Saccharomyces酵母的微生物分析,体外诱导L5178Y TK小鼠淋巴瘤细胞,以及肝细胞原代培养/DNA修复分析。在中国仓鼠卵巢(CHO)细胞中,它没有诱变性。
IDENTIFICATION AND USE: Dibutyl phenyl phosphate is a clear slightly yellow liquid. It is used in fire-resistant aircraft hydraulic fluids. HUMAN EXPOSURE AND TOXICITY: It produced marked pain in the eyes following contact; however, such contact has not been reported to cause damage to the eyes. Skin irritation has been described after prolonged skin contact. Exposure to aerosols or vapors produced nose and throat irritation accompanied by coughing and wheezing. ANIMAL STUDIES: It was not irritating to the eye in rabbits, but produced skin irritation upon repeated skin contact in the same species. It caused significant reduction of plasma cholinesterase activity in rabbits and in rats after prolonged exposure. The chemical did not cause organophosphorus compound-induced delayed neurotoxicity (OPIDN) in the adult hen. No teratogenic or fetotoxic effects were observed in the offspring of rats administered dibutyl phenyl phosphate by gavage. No mutagenic activity was seen when dibutyl phenyl phosphate was evaluated in the following systems: microbial assays with five Salmonella strains and one strain of Saccharomyces yeast, in vitro induction of L5178Y TK mouse lymphoma cells, and a hepatocyte primary culture/DNA repair assay. It was not mutagenic in Chinese hamster ovary (CHO) cells.
来源:Hazardous Substances Data Bank (HSDB)