monophytanyl hepta(ethylene glycol) tosylate | 423763-26-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: monophytanyl hepta(ethylene glycol) tosylate
• 英文别名: 2-[2-[2-[2-[2-[2-[2-[(7R,11R)-3,7,11,15-tetramethylhexadecoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
• CAS: 423763-26-2
• 化学式: C₄₁H₇₆O₁₀S
• 分子量: 761.114
• InChiKey: VNPRYXLYOYROBL-DNWKCNQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  52
• 可旋转键数：
  38
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  116
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  monophytanyl hepta(ethylene glycol) tosylate 在 sodium 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 25.5h， 生成 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(7R,11R)-3,7,11,15-tetramethylhexadecoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
  参考文献：
  名称：

  摘要：

  In order to optimize the performance of the AMBRI(TM) biosensor (Nature 1997, 387, 580), a variety of hydrophilic linkers between the hydrophobic bilayer membrane and the gold surface have been synthesized. The principal components are prepared from phytanyl hemisuccinate, which is linked by repeating ethylene glycol or propylene glycol units to a second succinic acid unit. The syntheses of analogous substances in which the ester links are replaced by amide and by ether links are also described.

  DOI：

  10.1071/ch01111
• 作为产物：
  描述：

  phytanyl bromide 在 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 25.5h， 生成 monophytanyl hepta(ethylene glycol) tosylate
  参考文献：
  名称：

  摘要：

  In order to optimize the performance of the AMBRI(TM) biosensor (Nature 1997, 387, 580), a variety of hydrophilic linkers between the hydrophobic bilayer membrane and the gold surface have been synthesized. The principal components are prepared from phytanyl hemisuccinate, which is linked by repeating ethylene glycol or propylene glycol units to a second succinic acid unit. The syntheses of analogous substances in which the ester links are replaced by amide and by ether links are also described.

  DOI：

  10.1071/ch01111