epi-5-[(2-hydroxyethyl)amino]-5-deoxyneamine | 1432025-30-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: epi-5-[(2-hydroxyethyl)amino]-5-deoxyneamine
• CAS: 1432025-30-3
• 化学式: C₁₄H₃₁N₅O₆
• 分子量: 365.43
• InChiKey: CTKFWGDUQHEEOM-VOMQWEQLSA-N

反应信息

• 作为产物：
  描述：

  在 palladium on activated charcoal 、 氢气 作用下， 以 四氢呋喃 、 水 、 溶剂黄146 为溶剂， 生成 epi-5-[(2-hydroxyethyl)amino]-5-deoxyneamine
  参考文献：
  名称：

  Neamine-heterocycle conjugates as potential anti-HIV agents

  摘要：

  A series of neamine-heterocycle conjugates were designed and synthesized. All new compounds displayed more potent inhibitory effect on HIV replication than neamine, among them two compounds displayed stronger anti-HIV activity than neomycin B. The results suggested that it might be a promising approach to modify neamine for the discovery of new anti-HIV agents. (C) 2013 Xiao-Lian Zhang, Xin-Shan Ye. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.03.009