2-Methyl-5-brompentanol | 26496-79-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-5-brompentanol
• 英文别名: 5-Bromo-2-methylpentan-1-ol
• CAS: 26496-79-7
• 化学式: C₆H₁₃BrO
• 分子量: 181.073
• InChiKey: RVEXOULBEQFFOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Methyl-5-brompentanol 在 咪唑 、 caesium carbonate 作用下， 以 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 、 N,N-二甲基甲酰胺 为溶剂， 反应 32.0h， 生成 tert-butyl-dimethyl-[2-methyl-5-(2-methylpyrazol-3-yl)oxypentoxy]silane
  参考文献：
  名称：

  [EN] INDAZOLE CONTAINING MACROCYCLES AND THEIR USE
  [FR] MACROCYCLES CONTENANT DE L'INDAZOLE ET LEUR UTILISATION

  摘要：

  The present disclosure relates to indazole containing macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as cancer.

  公开号：

  WO2023240138A1
• 作为产物：
  描述：

  5-bromo-2-methylpentanoic acid 在 硼烷二甲硫醚络合物 作用下， 以 四氢呋喃 为溶剂， 生成 2-Methyl-5-brompentanol
  参考文献：
  名称：

  [EN] INDAZOLE CONTAINING MACROCYCLES AND THEIR USE
  [FR] MACROCYCLES CONTENANT DE L'INDAZOLE ET LEUR UTILISATION

  摘要：

  The present disclosure relates to indazole containing macrocyclic compounds, pharmaceutical compositions containing macrocyclic compounds, and methods of using macrocyclic compounds to treat disease, such as cancer.

  公开号：

  WO2023240138A1

文献信息

• Ring-closing metathesis and palladium-catalyzed formate reduction to 3-methyleneoxepanes. Formal synthesis of (−)-zoapatanol
  作者：Hsiu-Yi Cheng、Yu-Shiang Lin、Chong-Si Sun、Ting-Wen Shih、Hui-Hsu Gavin Tsai、Duen-Ren Hou

  DOI：10.1016/j.tet.2011.10.023

  日期：2012.1

  A sequence of ring-closing metathesis and palladium-catalyzed formate reduction was developed for preparing O-heterocycles with an exocyclic olefin and applied to the asymmetric synthesis of zoapatanol. The key vicinal stereocenters in zoapatanol were constructed from the L-malic acid-derived lactone by successive chelation-controlled addition of alkyl groups. The O-allylations to prepare the dienes for RCM were achieved with the tertiary alcohols bearing internal olefins. The ring opening of oxepane, a new reaction pathway for the Pd-formate reduction, is also reported. (C) 2011 Elsevier Ltd. All rights reserved.