7,7-Dichloro-5-trimethylsilylhept-6-en-2-one | 1167443-86-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7,7-Dichloro-5-trimethylsilylhept-6-en-2-one
• 英文别名: 7,7-dichloro-5-trimethylsilylhept-6-en-2-one
• CAS: 1167443-86-8
• 化学式: C₁₀H₁₈Cl₂OSi
• 分子量: 253.244
• InChiKey: JNHWJJHMBQWHTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.38
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7,7-Dichloro-5-trimethylsilylhept-6-en-2-one 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以44%的产率得到
  参考文献：
  名称：

  A Flexible Radical-Based Approach to TMS-Substituted Propargyl Alcohols and to 2,3-Allenols

  摘要：

  The radical reaction of TMS-substituted xanthates with 2,2-dichlorovinyl ethyl sulfone afforded TMS-substituted homodichlorovinyl compounds that can be transformed into TMS-substituted propargyl alcohols. Various 2,3-allenols were efficiently prepared from the reaction of these TMS-substituted propargyl alcohols with TBAF.

  DOI：

  10.1021/ol900739x
• 作为产物：
  描述：

  ethyl β,β-dichlorovinyl sulfone 、 O-ethyl (4-oxo-1-trimethylsilylpentyl)sulfanylmethanethioate 在 二叔丁基过氧化物 作用下， 以 氯苯 为溶剂， 反应 12.17h， 以55%的产率得到7,7-Dichloro-5-trimethylsilylhept-6-en-2-one
  参考文献：
  名称：

  A flexible, modular route to cyclopentanols

  摘要：

  A flexible, modular route to cyclopentanols is devised based on a sequence of xanthate radical reactions followed by magnesium-mediated ketyl-olefin cyclization. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2009.09.157

文献信息

• A flexible, modular route to cyclopentanols
  作者：Zhi Li、Samir Z. Zard

  DOI：10.1016/j.tetlet.2009.09.157

  日期：2009.12

  A flexible, modular route to cyclopentanols is devised based on a sequence of xanthate radical reactions followed by magnesium-mediated ketyl-olefin cyclization. (C) 2009 Published by Elsevier Ltd.
• A Flexible Radical-Based Approach to TMS-Substituted Propargyl Alcohols and to 2,3-Allenols
  作者：Zhi Li、Samir Z. Zard

  DOI：10.1021/ol900739x

  日期：2009.7.2

  The radical reaction of TMS-substituted xanthates with 2,2-dichlorovinyl ethyl sulfone afforded TMS-substituted homodichlorovinyl compounds that can be transformed into TMS-substituted propargyl alcohols. Various 2,3-allenols were efficiently prepared from the reaction of these TMS-substituted propargyl alcohols with TBAF.