3β,13,23-trihydroxy-18α-oleanan-28-oic acid-13-lactone | 5664-03-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β,13,23-trihydroxy-18α-oleanan-28-oic acid-13-lactone
• 英文别名: 3β,13,23-Trihydroxy-18α-oleanan-28-saeure-13-lacton
• CAS: 5664-03-9
• 化学式: C₃₀H₄₈O₄
• 分子量: 472.709
• InChiKey: WWISNMQIUGGKBB-QTGAGAHLSA-N

物化性质

• 熔点：
  354 °C
• 沸点：
  596.9±50.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.88
• 重原子数：
  34.0
• 可旋转键数：
  1.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  66.76
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3β,13,23-trihydroxy-18α-oleanan-28-oic acid-13-lactone 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 13-hydroxy-3-oxo-24-nor-18α-oleanan-28-oic acid-lactone
  参考文献：
  名称：

  Phasic production of urinary pyridinium crosslinks in mice: The effect of ovariectomy

  摘要：

  Considerable sample to sample variability in deoxypyridinoline crosslink/creatinine (Dpd/CREAT) ratio values was confirmed when twice-weekly sampling for 77 days was performed in C57 mice. Analysis of samples from individual mice indicated that, in the majority of mice in a given group (54-67%), phasic changes occurred with peri odic peaks as much as 4-5 times basal values. Alignment of peaks in the individual time courses of mice revealed a clear cyclic crosslink production (periodicity 12-14 days) for the population. although not all mice gave a peak in every case. Ovariectomy (OVX) (compared to sham-operated mice) increased mean values of crosslink production by either C57 or C57 x 129 Fl mice from about 10 days after operation with highest values between 21 and 35 days, and then a decrease in the difference between sham and OVX, particularly in C57 mice. Analysis of both time courses for individual mice and distribution curves of the data from groups of mice indicated that OVX consistently increased basal crosslink values (6-9 ratio units) with phasic peak values superimposed. The peak alignment analysis reinforced this observation. The influence of the background variability was avoided by pooling data over one cycle time and the use of nonparametic statistics, and the effect of OVX was analyzed in several strains of mice. Crosslink levels and phasic production declined with age but were also influenced by manipulation of the mice, suggesting that experimental conditions should be rigorously controlled when this urinary crosslink measure is used as a parameter in mouse models of OVX-induced osteoporosis.

  DOI：

  10.1007/bf02678148
• 作为产物：
  描述：

  常春藤皂苷元 在 sodium hydroxide 作用下， 生成 3β,13,23-trihydroxy-18α-oleanan-28-oic acid-13-lactone
  参考文献：
  名称：

  Winterstein; Wiegand, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1931, vol. 199, p. 46,54

  摘要：

  DOI：

文献信息

• Winterstein; Meyer, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1931, vol. 199, p. 37,41
  作者：Winterstein、Meyer

  DOI：——

  日期：——
• 23. Melanthigenin and its identity with hederagenin
  作者：Zahira Mustafa、Gabra Soliman

  DOI：10.1039/jr9430000070

  日期：——
• Winterstein; Stein, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1932, vol. 211, p. 5,15
  作者：Winterstein、Stein

  DOI：——

  日期：——