3,7,11-trimethyl-dodeca-2,6,10-trienyl phenyl sulphoxide | 31163-06-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3,7,11-trimethyl-dodeca-2,6,10-trienyl phenyl sulphoxide
• 英文别名: [(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfinylbenzene
• CAS: 31163-06-1
• 化学式: C₂₁H₃₀OS
• 分子量: 330.535
• InChiKey: NPFOVRZVLRBGQB-YEFHWUCQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SYNTHESIS OF TOCOTRIENOLS FROM O-CRESOL DERIVATIVES<br/>[FR] SYNTHÈSE DE TOCOTRIÉNOLS À PARTIR DE DÉRIVÉS DE O-CRÉSOL
  申请人：ANTHEM BIOSCIENCES PRIVATE LTD

  公开号：WO2019053605A1

  公开（公告）日：2019-03-21

  The present invention provides an environmentally benign, facile process for preparation of Tocotrienols from commercially available derivatives of o-Cresol.

  本发明提供了一种环境友好、简便的工艺，用于从商业上可获得的邻甲酚衍生物制备生育三烯酚。
• US3944531A
  申请人：——

  公开号：US3944531A

  公开（公告）日：1976-03-16
• US4001339A
  申请人：——

  公开号：US4001339A

  公开（公告）日：1977-01-04
• [EN] METHOD AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF MENAQUINONE MK-7<br/>[FR] PROCÉDÉ ET COMPOSÉS INTERMÉDIAIRES POUR LA PRÉPARATION DE MÉNAQUINONE MK-7
  申请人：VITASYNTH SP Z O O

  公开号：WO2022015181A1

  公开（公告）日：2022-01-20

  The invention relates to a method and intermediate compounds for the preparation of menaquinone MK-7. The method for the preparation of menaquinone MK-7 is characterized in that, it comprises coupling of a compound of formula (11) with a compound of formula (17) in the presence of a base, to obtain a compound of formula (18), which is subjected to desulfonylation reaction in the presence of a palladium catalyst, to obtain a compound of formula (19), which is subjected to oxidation reaction, to obtain menaquinone MK-7. The invention also relates to compound (8), preferably in a crystalline form, which is a convenient intermediate compound for the preparation of menaquinone MK-7. (15 claims)