(-)(R)-3-iodo-heptane | 59614-81-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机碘化物
• 英文名称: (-)(R)-3-iodo-heptane
• 英文别名: (-)(R)-3-Jod-heptan；(3R)-3-iodoheptane
• CAS: 59614-81-2
• 化学式: C₇H₁₅I
• 分子量: 226.101
• InChiKey: LVPGHYVXKUXNQR-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  甲醇 、 (-)(R)-3-iodo-heptane 、 alkaline earth salt of/the/ methylsulfuric acid 生成 (+)(S)-3-azido-heptane
  参考文献：
  名称：

  Levene; Rothen; Kuna, Journal of Biological Chemistry, 1937, vol. 120, p. 789

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢碘酸 作用下， 生成 (-)(R)-3-iodo-heptane
  参考文献：
  名称：

  Levene; Rothen; Kuna, Journal of Biological Chemistry, 1937, vol. 120, p. 789

  摘要：

  DOI：

文献信息

• Round Window Gentamicin Absorption: An In Vivo Human Model
  作者：Zoran Becvarovski、Dennis I. Bojrab、Elias M. Michaelides、Jack M. Kartush、John J. Zappia、Michael J. LaRouere

  DOI：10.1097/00005537-200209000-00015

  日期：2002.9

  AbstractObjective/Hypothesis Using a novel human labyrinthine sampling model, in vivo gentamicin absorption through the round window can be measured.Study Design A prospective study.Methods Gentamicin was delivered either transtympanically (preoperative) or through a facial recess approach (intraoperative). The lateral semicircular canal and vestibule were opened, and by means of a microsyringe, labyrinthine fluid was aspirated. A sample of serum was also drawn. In all patients cerebrospinal fluid was also drawn. The samples were analyzed using a standard chemistry analyzer.Results Intratympanic gentamicin diffused through the round window membrane and achieved concentrations in the labyrinthine fluid ranging from 0 to 16 mg/L. Intratympanic gentamicin was absorbed into the systemic circulation in 4 of 11 patients with serum levels ranging from 0.3 to 0.4 mg/L. No gentamicin was detected in the cerebrospinal fluid.Conclusions Intratympanic gentamicin diffuses rapidly through the round window membrane and achieves significant levels in the inner ear. Thus, this new model can be used to assess round window permeability to clinically relevant medications such as steroids and ototopical antibiotics.