(3β,5α,14α,20R)-23-(1H-imidazol-2-yl)-4,4,14-trimethyl-24-norchol-8-en-3-ol | 138409-65-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (3β,5α,14α,20R)-23-(1H-imidazol-2-yl)-4,4,14-trimethyl-24-norchol-8-en-3-ol
• 英文别名: (3S,5R,10S,13R,14R,17R)-17-[(2R)-4-(1H-imidazol-2-yl)butan-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 138409-65-1
• 化学式: C₂₉H₄₆N₂O
• 分子量: 438.697
• InChiKey: AUDPHZXRKNUGBV-WJCUAGRGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  48.9
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3β,5α,14α,20R)-23-(1H-imidazol-2-yl)-4,4,14-trimethyl-24-norchol-8-en-3-ol 、 碘甲烷 在 sodium hydride 作用下， 生成 (3β,5α,14α,20R)-23-(1-methyl-1H-imidazol-2-yl)-4,4,14-trimethyl-24-norchol-8-en-3-ol
  参考文献：
  名称：

  Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans .DELTA.24-sterol methyltransferase

  摘要：

  A series of side chain modified analogues of cholesterol and lanosterol (1-10) have been synthesized and evaluated as inhibitors of the Candida albicans DELTA-24-sterol methyltransferase. Two sterol substrate analogues 1 and 2 which contained a 24-thia substituent were relatively modest inhibitors of the enzyme (K(i) = 1.5-72-mu-M). Compounds which mimic the carbocation intermediates proposed for the methyltransferase reaction, including sulfonium salts 4-6, amidines 7 and 8, and imidazoles 9 and 10 were substantially more potent inhibitors (K(i) = 5-500 nM). All of the sterol analogues examined displayed less than 10-fold selectivity for inhibition of the methyltransferase versus the rat liver DELTA-24-sterol reductase. The sterol analogues were tested for in vitro antifungal activity against C. albicans, Candida tropicalis, and Torulopsis glabrata. The minimum inhibitory concentrations versus C. albicans correlated well with the K(i) values for methyltransferase inhibition, and the potency of several compounds approached that of amphotericin B, although only modest fungicidal activity was observed.

  DOI：

  10.1021/jm00079a012
• 作为产物：
  描述：

  Trifluoro-acetic acid (3S,5R,10S,13R,14R,17R)-17-((R)-3-methoxycarbonimidoyl-1-methyl-propyl)-4,4,10,13,14-pentamethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester; compound with trifluoro-methanesulfonic acid 在 盐酸 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 74.0h， 生成 (3β,5α,14α,20R)-23-(1H-imidazol-2-yl)-4,4,14-trimethyl-24-norchol-8-en-3-ol
  参考文献：
  名称：

  Synthesis, specificity, and antifungal activity of inhibitors of the Candida albicans .DELTA.24-sterol methyltransferase

  摘要：

  A series of side chain modified analogues of cholesterol and lanosterol (1-10) have been synthesized and evaluated as inhibitors of the Candida albicans DELTA-24-sterol methyltransferase. Two sterol substrate analogues 1 and 2 which contained a 24-thia substituent were relatively modest inhibitors of the enzyme (K(i) = 1.5-72-mu-M). Compounds which mimic the carbocation intermediates proposed for the methyltransferase reaction, including sulfonium salts 4-6, amidines 7 and 8, and imidazoles 9 and 10 were substantially more potent inhibitors (K(i) = 5-500 nM). All of the sterol analogues examined displayed less than 10-fold selectivity for inhibition of the methyltransferase versus the rat liver DELTA-24-sterol reductase. The sterol analogues were tested for in vitro antifungal activity against C. albicans, Candida tropicalis, and Torulopsis glabrata. The minimum inhibitory concentrations versus C. albicans correlated well with the K(i) values for methyltransferase inhibition, and the potency of several compounds approached that of amphotericin B, although only modest fungicidal activity was observed.

  DOI：

  10.1021/jm00079a012