5,5-Bis(4-fluorophenyl)-9,9-bis(4-methylphenyl)non-8-en-6-yn-2-one | 1025362-75-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5,5-Bis(4-fluorophenyl)-9,9-bis(4-methylphenyl)non-8-en-6-yn-2-one
• 英文别名: 5,5-bis(4-fluorophenyl)-9,9-bis(4-methylphenyl)non-8-en-6-yn-2-one
• CAS: 1025362-75-7
• 化学式: C₃₅H₃₀F₂O
• 分子量: 504.619
• InChiKey: GEUJEHJPZFPKNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  、 丁烯酮 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以72%的产率得到5,5-Bis(4-fluorophenyl)-9,9-bis(4-methylphenyl)non-8-en-6-yn-2-one
  参考文献：
  名称：

  LDA-Mediated Selective Addition Reaction of Vinylidenecyclopropanes with Aldehydes, Ketones, and Enones: Facile Synthesis of Vinylcyclopropenes, Allenols, and 1,3-Enynes

  摘要：

  Highly selective addition reaction of vinylidenecyclopropanes 1 was realized by treatment with LDA in THF and quenching with aldehydes, ketones, and enones. A number of vinylcyclopropenes, allenols, and 1,3-enynes were obtained selectively in moderate to good yields depending on the nature of different electrophiles.

  DOI：

  10.1021/ol800463k

文献信息

• LDA-Mediated Selective Addition Reaction of Vinylidenecyclopropanes with Aldehydes, Ketones, and Enones: Facile Synthesis of Vinylcyclopropenes, Allenols, and 1,3-Enynes
  作者：Jian-Mei Lu、Min Shi

  DOI：10.1021/ol800463k

  日期：2008.5.1

  Highly selective addition reaction of vinylidenecyclopropanes 1 was realized by treatment with LDA in THF and quenching with aldehydes, ketones, and enones. A number of vinylcyclopropenes, allenols, and 1,3-enynes were obtained selectively in moderate to good yields depending on the nature of different electrophiles.