4-氯吲哚-3-甲醛 | 876-72-2

• 物质功能分类: 医药中间体 - 杂环化合物 - 吲哚类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 4-氯吲哚-3-甲醛
• 中文别名: 4-氯吲哚-3-醛
• 英文名称: 4-chloro-1H-indole-3-carbaldehyde
• 英文别名: 4-chloroindole-3-carboxaldehyde；4-chloro-3-indolecarbaldehyde
• CAS: 876-72-2
• 化学式: C₉H₆ClNO
• mdl: MFCD05864704
• 分子量: 179.606
• InChiKey: MSYJFNQAVTYKOP-UHFFFAOYSA-N

物化性质

• 熔点：
  164 °C
• 沸点：
  373.4±22.0 °C(Predicted)
• 密度：
  1.431±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2933990090
• 危险性防范说明：
  P305+P351+P338
• 危险性描述：
  H302,H319
• 储存条件：
  温度：2-8°C，保持在惰性气体氛围中。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 4-Chloroindole-3-carbaldehyde
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 4-Chloroindole-3-carbaldehyde
CAS number: 876-72-2

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C9H6ClNO
Molecular weight: 179.6

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-氯吲哚-3-甲醛 在 sodium chlorite 、 2-甲基-丁烯 作用下， 以93%的产率得到4-氯吲哚-3-羧酸
  参考文献：
  名称：

  Yamada, Fumio; Somei, Masanori, Heterocycles, 1987, vol. 26, # 5, p. 1173 - 1176

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯吲哚 在 N,N-二甲基甲酰胺 、 三氯氧磷 作用下， 反应 1.0h， 以65.8%的产率得到4-氯吲哚-3-甲醛
  参考文献：
  名称：

  The chemistry of indoles. XXIV. Syntheses of 3-indoleacetic acid and 3-indoleacetonitrile having a halogeno group and a carbon functional group at the 4-position.

  摘要：

  首次合成了多种4-卤代-3-吲哚乙酸和-3-吲哚乙腈，采用了桑德梅耶反应或施密特反应，展示了4-吲哚二氮盐在4-取代吲哚化学中的多样性。通过区域选择性的铊化-卤化开发了一种实用的4-卤代吲哚合成方法，所生成的产品也可转化为4-卤代-3-吲哚乙酸。此外，还报道了4-甲酰基-3-吲哚乙腈的首次合成。

  DOI：

  10.1248/cpb.33.3696

文献信息

• Visible-Light-Induced Trifluoromethylation of Isonitrile-Substituted Indole Derivatives: Access to 1-(Trifluoromethyl)-4,9-dihydro-3<i>H</i>-pyrido[3,4-b]indole and<i>β</i>-Carboline Derivatives
  作者：Jiaxin Liu、Longhai Li、Liuzhu Yu、Lisha Tang、Qin Chen、Min Shi

  DOI：10.1002/adsc.201800568

  日期：2018.8.6

  visible‐light‐induced trifluoromethylation of isonitrile‐substituted indole derivatives has been developed from the reaction of isonitrile‐substituted indoles with Togni II reagent, affording 1‐(trifluoromethyl)‐4,9‐dihydro‐3H‐pyrido[3,4‐b]indoles in moderate to good yields. The further transformations to β‐carboline derivatives and a harmacine derivative have been performed, demonstrating the potential synthetic

  的可见光诱导的异腈基取代的吲哚衍生物的三氟甲基化已经从与TOGNI II试剂异腈取代的吲哚的反应研制，得到1-（三氟甲基）-4,9-二氢-3- ħ -吡啶并[3,4 ‐b]吲哚产量中等至良好。已经进行了向β-咔啉衍生物和harmacine衍生物的进一步转化，证明了该方法的潜在合成效用。一项初步的生物学研究表明，含有CF 3的harmine类似物可显着刺激胰高血糖素样肽1（GLP-1）的分泌，表明糖尿病的治疗有所改善。
• Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling
  作者：Jason R. Abbott、Timothy R. Hodges、R. Nathan Daniels、Pratiq A. Patel、J. Phillip Kennedy、Jennifer E. Howes、Denis T. Akan、Michael C. Burns、Jiqing Sai、Tammy Sobolik、Yugandhar Beesetty、Taekyu Lee、Olivia W. Rossanese、Jason Phan、Alex G. Waterson、Stephen W. Fesik

  DOI：10.1021/acs.jmedchem.8b00360

  日期：2018.7.26

  Deregulated RAS activity, often the result of mutation, is implicated in approximately 30% of all human cancers. Despite this statistic, no clinically successful treatment for RAS-driven tumors has yet been developed. One approach for modulating RAS activity is to target and affect the activity of proteins that interact with RAS, such as the guanine nucleotide exchange factor (GEF) son of sevenless

  RAS 活性失调通常是突变的结果，约 30% 的人类癌症与此有关。尽管有这一统计数据，但尚未开发出针对 RAS 驱动肿瘤的临床成功治疗方法。调节 RAS 活性的一种方法是靶向并影响与 RAS 相互作用的蛋白质的活性，例如七同源物 1 (SOS1) 的鸟嘌呤核苷酸交换因子 (GEF)。在这里，我们报告了吲哚系列化合物的构效关系 (SAR)。使用基于结构的设计，我们系统地探索了吲哚核、悬垂氨基酸部分以及连接这两个片段的连接单元的取代模式。一流的化合物可在体外以亚微摩尔浓度激活核苷酸交换过程，提高 HeLa 细胞中活性 RAS-GTP 的水平，并引发丝裂原激活蛋白激酶 - 细胞外调节激酶 (MAPK-ERK) 通路中的信号传导变化，导致较高化合物浓度下pERK1/2 T202/Y204蛋白水平降低。
• Correction: Copper-mediated cyanation of indoles and electron-rich arenes using DMF as a single surrogate
  作者：Lianpeng Zhang、Ping Lu、Yanguang Wang

  DOI：10.1039/c6ob90012g

  日期：——

  Correction for ‘Copper-mediated cyanation of indoles and electron-rich arenes using DMF as a single surrogate’ by Lianpeng Zhang et al., Org. Biomol. Chem., 2015, 13, 8322–8329.

  “《有机生物分子化学》2015年第13卷8322-8329页的文章‘以DMF为单一替代试剂的铜介导的吲哚和富电子芳烃的氰化修正’的作者是Lianpeng Zhang等人。”
• Organocatalytic Formal (3 + 2) Cycloaddition toward Chiral Pyrrolo[1,2-<i>a</i>]indoles via Dynamic Kinetic Resolution of Allene Intermediates
  作者：Jian-Fei Bai、Lulu Zhao、Fang Wang、Fachao Yan、Taichi Kano、Keiji Maruoka、Yuehui Li

  DOI：10.1021/acs.orglett.0c01812

  日期：2020.7.17

  straightforward method to synthesize chiral pyrrolo[1,2-a]indole bearing a tetrasubstituted carbon stereocenter. The reaction proceeds smoothly with a wide array of substrate tolerance to deliver various chiral pyrrolo[1,2-a]indoles in up to 93% yield and 98% ee. The utility of this method is highlighted by the diverse transformations of the products into various indole derivatives.

  我们报道了手性磷酸催化的3-取代的1 H-吲哚和含有功能性导向基团（对-NHAc或对-OH）的炔丙醇的正式（3 + 2）环加成反应。这项工作代表了一种简单的方法来合成带有四取代碳立体中心的手性吡咯并[1,2- a ]吲哚。反应以多种底物耐受性顺利进行，以高达93％的收率和98％ee的产率递送各种手性吡咯并[1,2- a ]吲哚。通过将产物多样化转化为各种吲哚衍生物，突出了该方法的实用性。
• Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold
  作者：Anja Valdenaire、Julien Pothier、Dorte Renneberg、Markus A. Riederer、Oliver Peter、Xavier Leroy、Carmela Gnerre、Heinz Fretz

  DOI：10.1016/j.bmcl.2012.12.050

  日期：2013.2

  (E)-2-(3-(3-((3-Bromophenyl)amino)-2-cyano-3-oxoprop-1-en-1-yl)-1H-indol-1-yl)acetic acid (1) was discovered in a HTS campaign for CRTh2 receptor antagonists. An SAR around this hit could be established and representatives with interesting activity profiles were obtained. Ring closing tactics to convert this hit series into a novel 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole based CRTh2 receptor antagonist series is presented. (C) 2012 Elsevier Ltd. All rights reserved.

  (E)-2-(3-(3-((3-溴苯基)氨基)-2-羰基-3-丙酮-1-烯-1-yl)-1H-苯并azole-1-yl)乙酸（1）在HTS对CRTh2受体拮抗剂筛选中被发现。围绕此初筛物形成的SAR（结构活性关系研究）可以进行，可获得代表活性特性有趣的系列物。通过环闭合策略，将此初筛物系列转化为一种新型的2,3,4,5-四氢-1H-苯并[4,3-b]苯并azole基CRTh2受体拮抗剂系列。2012ElsevierLtd.所有权利保留。