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4-benzyloxy-2-hydroxy-3,5,6-trimethoxyacetophenone | 3162-49-0

中文名称
——
中文别名
——
英文名称
4-benzyloxy-2-hydroxy-3,5,6-trimethoxyacetophenone
英文别名
1-(2-hydroxy-3,5,6-trimethoxy-4-phenylmethoxyphenyl)ethanone
4-benzyloxy-2-hydroxy-3,5,6-trimethoxyacetophenone化学式
CAS
3162-49-0
化学式
C18H20O6
mdl
——
分子量
332.353
InChiKey
AOKAELZEDNBLMC-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 熔点:
    35–36°C
  • 沸点:
    483.8±40.0 °C(Predicted)
  • 密度:
    1.203±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    3.2
  • 重原子数:
    24.0
  • 可旋转键数:
    7.0
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.28
  • 拓扑面积:
    74.22
  • 氢给体数:
    1.0
  • 氢受体数:
    6.0

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Synthesis of 5,8-dihydroxy-6,7-dimethoxyflavones and revised structures for some natural flavones
    作者:T Horie
    DOI:10.1016/0031-9422(95)00070-n
    日期:1995.7
    7-trimethoxyflavones were synthesized from 2′,5′-dihydroxy-3′,4′,6′-trimethoxyacetophenone by adapting the selective O -alkylation and dealkylation, and the differentiation between the flavones and their isomeric 6-hydroxyflavones was clarified by 1 H NMR and UV spectra. Four natural flavones proposed as 5,8-dihydroxy-6,7-dimethoxyflavones, must have other structures and three are shown to be the isomeric
    摘要 以 2',5'-二羟基-3',4',6'-三甲氧基苯乙酮为原料,合成了 6 个 5,8-二羟基-6,7-二甲氧基黄酮和 3 个 8-羟基-5,6,7-三甲氧基黄酮。选择性O-烷基化和脱烷基化,黄酮和它们的异构体6-羟基黄酮之间的区别通过 1 H NMR 和紫外光谱得到澄清。四种天然黄酮被提议为 5,8-二羟基-6,7-二甲氧基黄酮,必须具有其他结构,其中三种被证明是异构的 5,7-二羟基-6,8-二甲氧基黄酮。从 Ageratum conyzoides 中分离出的黄酮被正确识别为 8-hydroxy-5,6,7,3',4',5'-六甲氧基黄酮,但从蜡菊中分离出的黄酮的结构被修改为异构体 7 -羟基-5,6,8-三甲氧基黄酮
  • Six 2′-hydroxyflavonols from Gutierrezia microcephala
    作者:Nianbai Fang、Mark Leidig、T.J. Mabry、Iinuma Munekazu
    DOI:10.1016/0031-9422(85)80050-9
    日期:1985.11
    Abstract Six 2′-hydroxyflavonols were isolated from Gutierrezia microcephala , including four new compounds, 5,7,2′-trihydroxy-3,6,4′,5′-tetramethoxyflavone, 5,7,2′-trihydroxy-3,6,8,4′,5′-pentamethoxyflavone, 5,2′-dihydroxy-3,6,7,8,4′,5′-hexamethoxyflavone and 5,7,2′,4′-tetrahydroxy-3,8,5′-trimethxoyflavone and two known compounds, 5,7,2′,5′-tetrahydroxy-3,6,8,4′-tetramethoxyflavone and 5,7,2′,4′-tetrahydroxy-3
    摘要 从 Gutierrezia microcephala 中分离得到 6 种 2'-羟基黄酮醇,包括 4 个新化合物,5,7,2'-三羟基-3,6,4',5'-四甲氧基黄酮,5,7,2'-三羟基-3,6 ,8,4',5'-五甲氧基黄酮,5,2'-二羟基-3,6,7,8,4',5'-六甲氧基黄酮和 5,7,2',4'-四羟基-3,8, 5'-三甲氧基黄酮和两种已知化合物,5,7,2',5'-四羟基-3,6,8,4'-四甲氧基黄酮和 5,7,2',4'-四羟基-3,6,8, 5'-四甲氧基黄酮
  • Iinuma, Munekazu; Tanaka, Toshiyuki; Mizuno, Mizuo, Chemical and pharmaceutical bulletin, 1986, vol. 34, # 5, p. 2228 - 2230
    作者:Iinuma, Munekazu、Tanaka, Toshiyuki、Mizuno, Mizuo、Mabry, Tom J.
    DOI:——
    日期:——
  • Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biological evaluations
    作者:Hiroto Sagara、Masaki Kanakogi、Yuki Tara、Hitoshi Ouchi、Junko Kimura、Yukiko Kaneko、Makoto Inai、Tomohiro Asakawa、Tomohisa Ishikawa、Toshiyuki Kan
    DOI:10.1016/j.tetlet.2018.03.064
    日期:2018.5
    We accomplished a divergent synthesis of sudachitin (2), a polymethoxyflavone isolated from citrus fruits, and six derivatives from acetophenone 9, which was an intermediate in our previous synthesis of nobiletin (1). Compound 2 enhanced glucose-induced insulin secretion in INS-1D cells, but was less potent than 1. Compared with 1, compound 2 and two derivatives were more potent inhibitors of cAMP-specific phosphodiesterase. (C) 2018 Published by Elsevier Ltd.
  • 496. Syntheses of flavones from Lindera lucida
    作者:H. H. Lee、C. H. Tan
    DOI:10.1039/jr9650002743
    日期:——
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