2-azido-1-(4'-methoxyphenyl)-pentan-1-one | 612824-85-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-azido-1-(4'-methoxyphenyl)-pentan-1-one
• 英文别名: 2-azido-1-(4-methoxyphenyl)pentan-1-one
• CAS: 612824-85-8
• 化学式: C₁₂H₁₅N₃O₂
• 分子量: 233.27
• InChiKey: ZMAKADHEMPAVOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  40.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-azido-1-(4'-methoxyphenyl)-pentan-1-one 在 水 、 三苯基膦 、 air 、 溶剂黄146 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 4.0h， 以82%的产率得到2,5-bis-n-propyl-3,6-bis-(4'-methoxyphenyl)-pyrazine
  参考文献：
  名称：

  Estrogenic diazenes: heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes

  摘要：

  Estrogens regulate many biological functions, often acting in a tissue-selective manner. Their tissue-selective action is believed to involve differential estrogen action through the two estrogen receptor (ER) subtypes, ERalpha and ERbeta, as well as differential interaction of the ligand-receptor complexes with promoters and coregulator proteins. In the latter case, selectivity is based on the induction of specific conformations of the ligand-ER complex, conformations that are influenced by the structure of the ligand. Estrogen pharmaceuticals having an ideal balance of tissue-selective activity are being sought for menopausal hormone replacement, breast cancer prevention and therapy, and other actions. To expand on the structural diversity of ER ligands that might show such tissue selectivity, we have prepared a series of diazenes (pyrazines, pyrimidines, and pyridazines) substituted with two to four aryl groups and various short-chain aliphatic substituents. All of the pyrazine and pyrimidines bind to ER, some with high affinity and with a considerable degree of preferential binding to either ERalpha or ERbeta. One pyrimidine and one pyrazine have ERalpha affinity preferences as high as 23 and 9, respectively, and one pyrimidine has an ERP affinity preference of 8. The pyridazines, by contrast, are quite polar and have only very low binding affinity for the ER. In cell-based transcription assays, several of the pyrimidines and a pyrazine were found to be considerably more agonistic on ERalpha than on ERbeta. Because these triaryl diazenes have the largest volumes among the ER ligands so far investigated, their high affinity demonstrates the flexibility of the ligand binding pocket of the ERs and its tolerance for large substituents. Thus, these novel heterocyclic ligands expand the repertoire of chemical structures that bind to the estrogen receptor, and they could prove to be useful in elucidating the biological behavior of the two ER subtypes and in forming the basis for new estrogen pharmaceuticals having desirable tissue selectivity. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00309-7
• 作为产物：
  描述：

  4-甲氧基苯戊酮 在 sodium azide 、 溴 作用下， 以 乙醚 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 2-azido-1-(4'-methoxyphenyl)-pentan-1-one
  参考文献：
  名称：

  Au（III）和Bi（III）催化的苯甲酰化反应中的动力学非对映异构体分化：2-氨基-1,1-二芳基烷烃的简明和立体控制合成

  摘要：

  携带在烷烃链的相邻α硝基或α-叠氮基苄醇被转化成顺式-1,1-二芳基-2-硝基-和2- azidoalkanes与由布朗斯台德酸和路易斯酸催化的立体选择性反应的富电子的芳烃。发现氯化金（III）和三氟甲磺酸铋（III）作为催化剂特别有效，在非对映异构体α-取代的苄醇的反应性中表现出动力学控制的差异。预计将其用于治疗相关的顺式和反式2-氨基-1,1-二芳基烷烃。

  DOI：

  10.1021/ol500902p