4-hydrazineyl-2-methylbutan-2-ol | 432509-15-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-hydrazineyl-2-methylbutan-2-ol
• 英文别名: 4-hydrazinyl-2-methyl-2-Butanol；4-hydrazinyl-2-methylbutan-2-ol
• CAS: 432509-15-4
• 化学式: C₅H₁₄N₂O
• mdl: MFCD21859482
• 分子量: 118.179
• InChiKey: CPDGOTPXOYUCNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-hydrazineyl-2-methylbutan-2-ol 在 sodium hydride 、 六甲基二硅氮烷 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 43.83h， 生成 3-(2-chloro-6-fluorophenyl)-5-(5-(difluoromethyl)-1-(3-methyl-3-((trimethylsilyl)oxy)butyl)-1H-pyrazol-4-yl)-4-(pyrimidin-2-yl)isoxazole
  参考文献：
  名称：

  [EN] METHODS FOR TREATING CANCER
  [FR] MÉTHODES DE TRAITEMENT DU CANCER

  摘要：

  The present invention provides methods comprising one or compounds according to Formula (I) alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g. prostate cancer, such as castration-resistant prostate cancer (CRPC) and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, lymphoma and glioma.

  公开号：

  WO2023281097A1
• 作为产物：
  描述：

  3-羟基-3-甲基对甲苯磺酸丁酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 4-hydrazineyl-2-methylbutan-2-ol
  参考文献：
  名称：

  [EN] METHODS FOR TREATING CANCER
  [FR] MÉTHODES DE TRAITEMENT DU CANCER

  摘要：

  The present invention provides methods comprising one or compounds according to Formula (I) alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g. prostate cancer, such as castration-resistant prostate cancer (CRPC) and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, lymphoma and glioma.

  公开号：

  WO2023281097A1