(1S:2R:4S)-p-menthanediol-(2.8) | 19956-45-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1S:2R:4S)-p-menthanediol-(2.8)
• 英文别名: (1S)-1r-Methyl-4t-(α-hydroxy-isopropyl)-cyclohexanol-(2c)；(1S:2R:4S)-p-Menthandiol-(2.8)；(1S,2R,4S)-p-Menthan-2,8-diol；Einecs 266-986-1；(1R,2S,5S)-5-(2-hydroxypropan-2-yl)-2-methylcyclohexan-1-ol
• CAS: 19956-45-7
• 化学式: C₁₀H₂₀O₂
• 分子量: 172.268
• InChiKey: QTJUHINKPNOAEU-XHNCKOQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1S:2R:4S)-p-menthanediol-(2.8) 在 硫酸 作用下， 生成 dihydropinol
  参考文献：
  名称：

  Schmidt, Chemische Berichte, 1955, vol. 88, p. 459,466

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 钯 、 溶剂黄146 、 铂 作用下， 生成 (1S:2R:4S)-p-menthanediol-(2.8)
  参考文献：
  名称：

  Iyer; Simonsen, Journal of the Chemical Society, 1926, p. 2052

  摘要：

  DOI：

文献信息

• METHOD FOR TREATING AN AUTOIMMUNE NEUROLOGICAL DISEASE AND/OR NEURODEGENERATIVE DISEASE AND PHARMACEUTICAL FORMULATIONS FOR A LIQUID DOSAGE FORM AND A CONTROLLED RELEASE DOSAGE FORM
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：US20190000776A1

  公开（公告）日：2019-01-03

  A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: wherein is a single or double bond, X is NCH 3 or CH 2 , Y is null, O or N, R 1 is H, OH, and R 2 is null, H, C 1 -C 8 alkyl, —(C═O)-alkyl, —(C═O)-aryl, —(C═O)-alkyl-aryl, —(C═O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of —OH, —NO 2 , —NH 2 , —NR 3 R 4 , carbonyl, alkoxyl, alkyl or —OCF 3 , wherein R 3 and R 4 independently are H, alkyl, —SO 2 CH 3 , —(C═O)—CH 3 or —(C═O)—NH 2 .
• MULTI-PARTICULATE PHARMACEUTICAL COMPOSITION, IMMEDIATE RELEASE PELLETS, SUSTAINED RELEASE PELLETS, ENTERIC RELEASE PELLETS AND USE THEREOF
  申请人：Industrial Technology Research Institute

  公开号：US20210290557A1

  公开（公告）日：2021-09-23

  A multi-particulate pharmaceutical composition includes mixture pellets including at least two of the following pellets: a first immediate-release pellet, a sustained-release pellet, an enteric-release pellet and an enteric coated sustained-release pellet.
• PHARMACEUTICAL FORMULATIONS FOR A LIQUID DOSAGE FORM AND A CONTROLLED RELEASE DOSAGE FORM
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：US20220249395A1

  公开（公告）日：2022-08-11

  A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: wherein is a single or double bond, X is NCH 3 or CH 2 , Y is null, O or N, Z is O or N, R 1 is H, OH, and R 2 is null, H, C 1 -C 8 alkyl, —(C═O)-alkyl, —(C═O)-aryl, —(C═O)-alkyl-aryl, —(C═O)-heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of —OH, —NO 2 , —NH 2 , —NR 3 R 4 , carbonyl, alkoxyl, alkyl or —OCF 3 , wherein R 3 and R 4 independently are H, alkyl, O 2 CH 3 , —(C═O)—CH 3 or (C═O)—NH 2 .
• [EN] METHOD FOR TREATING AN AUTOIMMUNE NEUROLOGICAL DISEASE AND/OR NEURODEGENERATIVE DISEASE AND PHARMACEUTICAL FORMULATIONS FOR A LIQUID DOSAGE FORM AND A CONTROLLED RELEASE DOSAGE FORM<br/>[FR] PROCÉDÉ DE TRAITEMENT D'UNE MALADIE NEUROLOGIQUE AUTO-IMMUNE ET/OU D'UNE MALADIE NEURODÉGÉNÉRATIVE ET FORMULES PHARMACEUTIQUES POUR UNE FORME GALÉNIQUE LIQUIDE ET UNE FORME GALÉNIQUE À LIBÉRATION CONTRÔLÉE
  申请人：IND TECH RES INST

  公开号：WO2019002889A1

  公开（公告）日：2019-01-03

  A method for treating an autoimmune neurological disease and/or a neurodegenerative disease is provided. The method includes administering an effective amount of at least one compound having Formula (I), Formula (II) or Formula (III), or its geometric isomer, enantiomer or diastereomer to a subject in need thereof: Formula (I); Formula (II); Formula (III), wherein is a single or double bond, X is NCH3 or CH2, Y is null, O or N, R1 is H, OH, and R2 is null, H, C1-C8 alkyl, -(C=O)–alkyl, –(C=O)–aryl, –(C=O)–alkyl-aryl, –(C=O)–heteroaryl, cycloalkyl or heterocycloalkyl, which optionally substituted by one or more of -OH, -NO2, -NH2, -NR3R4, carbonyl, alkoxyl, alkyl or -OCF3, wherein R3 and R4 independently are H, alkyl, -SO2CH3, -(C=O)-CH3 or -(C=O)-NH2.
• Schmidt, Chemische Berichte, 1955, vol. 88, p. 459,466
  作者：Schmidt

  DOI：——

  日期：——