(2S)-2-fluorohexan-1-ol | 127608-47-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: (2S)-2-fluorohexan-1-ol
• 英文别名: S-(-)-2-fluorohexanol；2-fluoro-n-hexan-1-ol
• CAS: 127608-47-3
• 化学式: C₆H₁₃FO
• 分子量: 120.167
• InChiKey: NVIVQGNQOLBSLT-LURJTMIESA-N

物化性质

• 沸点：
  159.3±10.0 °C(Predicted)
• 密度：
  0.917±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2S)-2-fluorohexan-1-ol 在 氯化亚砜 、 硝酸 、 sodium acetate 作用下， 以 溶剂黄146 、 苯 为溶剂， 生成 (S)-2-Fluoro-hexanoyl chloride
  参考文献：
  名称：

  Nakamura, S.; Nohira, H., Molecular Crystals and Liquid Crystals (1969-1991), 1990, vol. 185, p. 199 - 207

  摘要：

  DOI：
• 作为产物：
  描述：

  (S)-(-)-2-fluorohexanoic acid 在 lithium aluminium tetrahydride 作用下， 生成 (2S)-2-fluorohexan-1-ol
  参考文献：
  名称：

  ENANTIOMERICALLY PURE ETHYL (R)- AND (S)- 2-FLUOROHEXANOATE BY ENZYME-CATALYZED KINETIC RESOLUTION

  摘要：

  DOI：

  10.15227/orgsyn.069.0010

文献信息

• Diastereoselective fluorination of chiral imide enolates using n-fluoro-o-benzenedisulfonimide (nfobs)
  作者：Franklin A. Davis、Wei Han

  DOI：10.1016/s0040-4039(00)91883-5

  日期：1992.2

  α-Fluoro acids (78–90% ee) and β-fluoro alcohols (89–>95%ee) of well defined stereochemistry are prepared via the diastereoselective fluorination of chiral imide enolates with NFOBS (3).

  定义明确的立体化学的α-氟酸（78-90％ee）和β-氟醇（89-> 95％ee）是通过使用NFOBS对手性酰亚胺烯酸酯进行非对映选择性氟化而制得的（3）。
• NOVEL COMPOUNDS AND METHODS FOR SYNTHESIS AND THERAPY
  申请人：BISCHOFBERGER NORBERT W.

  公开号：US20050176758A1

  公开（公告）日：2005-08-11

  Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

  本发明涉及新型化合物。该化合物通常包含一个酸性基团、一个碱性基团、一个取代的氨基或N-酰基和一个具有可选羟基化的烷基部分。本发明还涉及包含所述抑制剂的制药组合物。还描述了用于抑制怀疑含有神经氨酸酶的样品中神经氨酸酶的方法。还描述了抗原材料、聚合物、抗体、标记化合物的结合物以及用于检测神经氨酸酶活性的测定方法。
• A ferroelectric liquid-crystalline polymeric composition
  申请人：IDEMITSU KOSAN COMPANY LIMITED

  公开号：EP0310081A2

  公开（公告）日：1989-04-05

  The liquid-crystalline polymeric composition of the invention comprises (A) a non-liquid-crystalline polymeric compound and (B) a low-molecular liquid-crystalline compound each having a proton donor and/or a proton acceptor in the molecular structure and the low-molecular compound has a chiral smectic C phase. By virtue of these functional groups forming hydrogen bonds between the components, the liquid-crystalline polymeric composition of the invention is not a mere blend of the components liable to cause phase separation but is imparted with greatly increased stability and uniformity of the blend as well as responsivity of high speed.

  本发明的液晶聚合物组合物包括(A)非液晶聚合物化合物和(B)低分子液晶化合物，每种化合物的分子结构中都有质子供体和/或质子受体，且低分子化合物具有手性 Smectic C 相。由于这些官能团在各组分之间形成氢键，本发明的液晶聚合物组合物不再是容易导致相分离的单纯组分混合物，而是大大提高了混合物的稳定性和均匀性以及高速响应性。
• A General Organocatalyst for Direct α-Functionalization of Aldehydes:  Stereoselective C−C, C−N, C−F, C−Br, and C−S Bond-Forming Reactions. Scope and Mechanistic Insights
  作者：Johan Franzén、Mauro Marigo、Doris Fielenbach、Tobias C. Wabnitz、Anne Kjærsgaard、Karl Anker Jørgensen

  DOI：10.1021/ja056120u

  日期：2005.12.1

  The development of a general organocatalyst for the alpha-functionalization of aldehydes, via an enamine intermediate, is presented. Based on optically active alpha,alpha-diarylprolinol silyl ethers, the scope and applications of this catalyst for the stereogenic formation of C-C, C-N, C-F, C-Br, and C-S bonds are outlined. The reactions all proceed in good to high yields and with excellent enantioselectivities. Furthermore, we will present mechanistic insight into the reaction course applying nonlinear effect studies, kinetic resolution, and computational investigations leading to an understanding of the properties of the alpha,alpha-diarylprolinol silyl ether catalysts.
• Nohira, H.; Nakamura, S.; Kamei, M., Molecular Crystals and Liquid Crystals (1969-1991), 1990, vol. 180, p. 379 - 388
  作者：Nohira, H.、Nakamura, S.、Kamei, M.

  DOI：——

  日期：——