4-溴-6,8-二氟-2-甲基喹啉 | 1189106-86-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-溴-6,8-二氟-2-甲基喹啉
• 英文名称: 4-bromo-6,8-difluoro-2-methylquinoline
• CAS: 1189106-86-2
• 化学式: C₁₀H₆BrF₂N
• 分子量: 258.065
• InChiKey: BMDJTKNFPQFHEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  4-溴-6,8-二氟-2-甲基喹啉 、 4-Imidazo[1,2-a]pyridin-7-yl-benzaldehyde 在 potassium acetate 、 palladium diacetate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  Discovery, synthesis and characterization of a series of 7-aryl-imidazo[1,2-a]pyridine-3-ylquinolines as activin-like kinase (ALK) inhibitors

  摘要：

  The activin-like kinases are a family of kinases that play important roles in a variety of disease states. Of this class of kinases, ALK2, has been shown by a gain-of-function to be the primary driver of the childhood skeletal disease fibrodysplasia ossificans progressiva (FOP) and more recently the pediatric cancer diffuse intrinsic pontine glioma (DIPG). Herein, we report our efforts to identify a novel imidazo[1,2-a]pyridine scaffold as potent inhibitors of ALK2 with good in vivo pharmacokinetic properties suitable for future animal studies.

  DOI：

  10.1016/j.bmcl.2020.127418

文献信息

• Inhibition of BMP signaling, compounds, compositions and uses thereof
  申请人：Vanderbilt University

  公开号：US10745400B2

  公开（公告）日：2020-08-18

  Provided herein are substituted imidazo[1,2-a]pyridines useful as inhibitors of BMP signaling. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted imidazo[1,2-a]pyridines.

  本发明提供了可用作 BMP 信号转导抑制剂的取代咪唑并[1,2-a]吡啶。本发明进一步提供了本发明化合物的药物组合物。本发明还提供了取代的咪唑并[1,2-a]吡啶的医疗用途。
• INHIBITION OF BMP SIGNALING, COMPOUNDS, COMPOSITIONS AND USES THEREOF
  申请人：Vanderbilt University

  公开号：US20190284183A1

  公开（公告）日：2019-09-19

  Provided herein are substituted imidazo[1,2-a]pyridines useful as inhibitors of BMP signaling. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted imidazo[1,2-a]pyridines.