Ala-Thr | 1115-34-0

• 物质功能分类: 生物化工 - 生化试剂 - 氨基酸
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ala-Thr
• 英文别名: L-alanyl-L-threonine；N-L-alanyl-L-threonine；(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-hydroxybutanoic acid
• CAS: 1115-34-0；24032-50-6；40355-99-5；40356-05-6；91605-37-7；92841-56-0；129645-51-8
• 化学式: C₇H₁₄N₂O₄
• 分子量: 190.199
• InChiKey: BUQICHWNXBIBOG-DSDZBIDZSA-N

物化性质

• 沸点：
  471.0±45.0 °C(Predicted)
• 密度：
  1.294±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Ala-Thr 在 盐酸 、 亚硝酸特丁酯 、 硫化氢 、 mercury(II) diacetate 、 三乙胺 作用下， 反应 0.17h， 生成 Cys-Ala-Gly-Ala-Thr-TFA
  参考文献：
  名称：

  Kawasaki, Koichi; Maeda, Mitsuko; Tamura, Hiromi, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 5, p. 1717 - 1723

  摘要：

  DOI：
• 作为产物：
  描述：

  3-hydroxy-2-[2-(phenylmethoxycarbonylamino)propanoylamino]butanoic acid 在 氢气 作用下， 生成 Ala-Thr
  参考文献：
  名称：

  Kawasaki, Koichi; Maeda, Mitsuko; Tamura, Hiromi, Chemical and pharmaceutical bulletin, 1984, vol. 32, # 5, p. 1717 - 1723

  摘要：

  DOI：

文献信息

• Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method
  申请人：Tonouchi Naoto

  公开号：US20050037453A1

  公开（公告）日：2005-02-17

  The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having the ability to produce a dipeptide from an L-amino acid ester and an L-amino acid, using microbial cells isolated from the culture, or a treated microbial cell product of the microbe.

  本发明提供了一种使用成本低廉的起始材料通过工业上有利且简单的途径生产二肽的方法。通过使用具有从L-氨基酸酯和L-氨基酸生产二肽的能力的微生物培养物，使用从培养物中分离出的微生物细胞或经处理的微生物细胞产物，从L-氨基酸酯和L-氨基酸生产二肽。
• Process for producing dipeptide,l-amino acid amide hydrolase to be used therein and process for producing l-amino acid amide hydrolase
  申请人：Nozaki Hiroyuki

  公开号：US20050054067A1

  公开（公告）日：2005-03-10

  A process for industrially advantageously producing a dipeptide via a convenient pathway starting with less expensive and easily available materials is provided. A dipeptide is produced from an L-amino acid amide and an L-amino acid by using a culture of a microbe capable of synthesizing the dipeptide from the L-amino acid amide and the L-amino acid, microbial cells separated from the culture or a treated microbial cell product from the microbe. An L-amino acid amide hydrolase is obtained from a microbe belonging to the genus erwinia, genus Rhodococcus, genus Chryseobacterium, genus Micrococcus, genus Cryptococcus, genus Trichosporion, genus Rhodosporidium, genus Sporobolomyces, genus Tremela, genus Torulaspora, genus Sterigmatomyces or genus Rhodotorula. The hydrolase catalyzes a reaction that produces a dipeptide from an L-amino acid amide and an L-amino acid.

  提供一种工业上优势的方法，通过一个便捷的途径，使用成本较低且易得的材料开始，生产二肽。通过使用能够从L-氨基酸酰胺和L-氨基酸合成二肽的微生物培养物，从培养物中分离的微生物细胞或经过处理的微生物细胞产物来制备二肽。从属于Erwinia属，Rhodococcus属，Chryseobacterium属，Micrococcus属，Cryptococcus属，Trichosporion属，Rhodosporidium属，Sporobolomyces属，Tremela属，Torulaspora属，Sterigmatomyces属或Rhodotorula属的微生物中获得L-氨基酸酰胺水解酶。该水解酶催化从L-氨基酸酰胺和L-氨基酸产生二肽的反应。
• MUTANT PROTEIN HAVING THE PEPTIDE-SYNTHESIZING ACTIVITY
  申请人：ABE Isao

  公开号：US20070292916A1

  公开（公告）日：2007-12-20

  The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations 1 to 68, and the mutations 239 to 290 and 324 to 377 in an amino acid sequence of SEQ ID NO:2. (II) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations L1 to L335 and M1 to M642 in an amino acid sequence of SEQ ID NO:208

  本发明旨在提供一种优秀的肽合成蛋白质及高效生产肽的方法。在以下（I）和（II）所示的蛋白质的至少一种存在下，通过在胺组分和羧组分存在下反应合成肽。其中，（I）为突变蛋白质，其氨基酸序列包括来自于突变1至突变68、突变239至突变290和突变324至突变377的一个或多个突变；（II）为突变蛋白质，其氨基酸序列包括来自于L1至L335和M1至M642的一个或多个突变。
• Mutant protein having the peptide-synthesizing activity
  申请人：Abe Isao

  公开号：US20070190602A1

  公开（公告）日：2007-08-16

  The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations 1 to 68, and the mutations 239 to 290 and 324 to 377 in an amino acid sequence of SEQ ID NO:2. (II) The mutant protein having an amino acid sequence comprising one or more mutations from any of the mutations L1 to L335 and M1 to M642 in an amino acid sequence of SEQ ID NO:208

  本发明旨在提供一种优异的合成肽蛋白质及高效生产肽的方法。在以下(I)和(II)所示的蛋白质的存在下，通过反应胺组分和羧基组分来合成肽。(I)突变蛋白质的氨基酸序列包括来自突变1到68和突变239到290以及SEQ ID NO:2的氨基酸序列中的突变324到377中的一个或多个突变。(II)突变蛋白质的氨基酸序列包括来自突变L1到L335和M1到M642和SEQ ID NO:208的氨基酸序列中的一个或多个突变。
• Dipeptide production method, L-amino acid amide hydrolase used therein, and production method of L-amino acid amide hydrolase
  申请人：Nozaki Hiroyuki

  公开号：US20070042459A1

  公开（公告）日：2007-02-22

  A process for industrially advantageously producing a dipeptide via a convenient pathway starting with less expensive and easily available materials is provided. A dipeptide is produced from an L-amino acid amide and an L-amino acid by using a culture of a microbe capable of synthesizing the dipeptide from the L-amino acid amide and the L-amino acid, microbial cells separated from the culture or a treated microbial cell product from the microbe. An L-amino acid amide hydrolase is obtained from a microbe belonging to the genus erwinia, genus Rhodococcus, genus Chryseobacterium, genus Micrococcus, genus Cryptococcus, genus Trichosporion, genus Rhodosporidium, genus Sporobolomyces, genus Tremela, genus Torulaspora, genus Sterigmatomyces or genus Rhodotorula. The hydrolase catalyzes a reaction that produces a dipeptide from an L-amino acid amide and an L-amino acid.

  提供了一种通过方便的途径从成本较低且易获得的材料开始，工业上有利地生产二肽的过程。使用能够从L-氨基酸酰胺和L-氨基酸合成二肽的微生物培养物、从培养物中分离的微生物细胞或经过处理的微生物细胞产物来从L-氨基酸酰胺和L-氨基酸中生产二肽。从属于Erwinia属、Rhodococcus属、Chryseobacterium属、Micrococcus属、Cryptococcus属、Trichosporion属、Rhodosporidium属、Sporobolomyces属、Tremela属、Torulaspora属、Sterigmatomyces属或Rhodotorula属的微生物中获得L-氨基酸酰胺水解酶。该水解酶催化从L-氨基酸酰胺和L-氨基酸生成二肽的反应。